Description
Oxandrolone (Anavar, Oxandrin) is a synthetic dihydrotestosterone derivative with a 2-oxa modification that extends the steroid scaffold at the A-ring by one oxygen atom. The additional 17α-methyl group enables oral bioavailability without immediate first-pass breakdown.
Per study reports Oxandrolone is considered the mildest of classical 17α-methyl steroids. Clinically the substance was long approved for recovery after severe burns and for HIV wasting treatment. Anabolic action is moderate, androgenic activity low, aromatization practically absent.
Pharmacokinetically orally bioavailable with about 8-10 hour half-life, requiring two daily doses. Steady-state within 2-3 days. Bioavailability is very high at about 95% - a consequence of the 2-oxa modification that reduces first-pass hepatic metabolism.
In recreational research practice Oxandrolone is the standard compound for cutting phases and women’s research setups (low virilization incidence). Hepatotoxicity is lower than under classical 17α-methyl steroids like Dianabol or Anadrol but not zero - longer cycles need liver monitoring.
Known effects in studies: marked decrease in HDL and increase in LDL, mild ALT/AST elevation, low HPG axis suppression compared to other orals. Anavar is on the WADA banned list.
You can order Oxandrolone as oral tablets in one bottle with 20mg per tablet.
This information is for research and educational purposes only. No medical recommendations.
Risks & Safety
Oxandrolone is considered the mildest of the classical 17α-methyl steroids per study reports, yet still sits clearly in the upper range of the risk scale. The effects documented in the literature are milder than under Dianabol or Anadrol, but not negligible.
Documented in studies and the user literature:
- Liver strain: Oxandrolone is 17α-methylated. Mild ALT/AST elevations are documented. Liver monitoring is advised in the literature for longer protocols.
- Lipid profile: studies describe a marked decrease in HDL and an increase in LDL, regarded as an unfavorable cardiovascular shift.
- Suppression of natural production: suppression of the HPG axis is documented, lower than under other orals but present.
- Virilization: despite low androgenic activity, virilization effects at higher doses are described in the literature.
This classification does not replace medical advice. Risk and responsibility for any actual use lie entirely with the buyer.
Studies
- Use of Oxandrolone in Burn Patients - Journal of Burn Care and Research 2006, Przkora et al: Clinical evaluation of oxandrolone in rehabilitation after severe burns.
- The Anabolic Androgenic Steroid Oxandrolone in the Treatment of Wasting and Catabolic Disorders - Drugs 2004, Orr et al: Review of indications, pharmacokinetics and safety profile in catabolic states including HIV wasting.
- Resistance Exercise and Oxandrolone for Men With HIV-Related Weight Loss - JAMA 2000, Fontanarosa et al: Study on the combination of oxandrolone and resistance training in HIV-associated weight loss.
- Incidence of Hepatic Dysfunction Is Equivalent in Burn Patients Receiving Oxandrolone and Controls - Journal of Burn Care and Research 2007, McCullough et al: Hepatic safety study of oxandrolone therapy in burn patients.
- Oxandrolone for growth-hormone treated children and adolescents with Turner syndrome - Cochrane Database of Systematic Reviews 2013, Mohamed et al: Cochrane review on growth effects in Turner syndrome.
