Sustanon 300

Each ester is released from the oil depot at a different speed. After a single injection of the blend all four esters were detectable in blood and how long depended on the ester. A short ester like propionate kept levels above the normal range for about 48 hours in one study while long esters last much longer. At the receptor it is always testosterone in the end.

For this strength we found neither a study nor a registry entry. The components are approved: the ChEMBL database lists testosterone and testosterone propionate as drugs and the classic four-ester blend appears in phase 4 trials on the registry. Testosterone is banned in sport. Everything here is the state of research, not a recommendation.

There is more compound per ml, so the same amount needs less volume. At the receptor it is the same testosterone. In a trial with five dose levels over 20 weeks fat-free mass and haemoglobin rose with the testosterone level while HDL cholesterol fell. In monkeys the release profile shaped the effect more than the total amount.

18 healthy men aged 65 to 75 did 6 weeks of weight training and got the classic four-ester blend or placebo every 2 weeks. With testosterone fat-free mass, leg mass, muscle thickness and strength rose more while fat mass fell. Net protein gain in muscle was 8.3 g per day versus 1.9 g with placebo. The study ran for only 6 weeks with 9 people per group.

Testosterone from outside suppresses the hormone axis. In healthy young men LH and the testicular marker INSL3 fell on the blend and returned to baseline after stopping. In a rat study the testes shrank and sperm count, LH and FSH fell.

In dried blood spots all four esters were measurable for at least 5 days after two injections and three of them for up to 14 days. Blood values changed too: the blood profile was flagged in 6 of 9 men, most clearly the share of young red blood cells 3 to 10 days after the injection.

The Endocrine Society describes a higher risk of cardiovascular, liver, kidney, hormonal and psychiatric disorders for performance-enhancing drugs in high amounts. Controlled trials with such amounts hardly exist for ethical reasons. With the blend itself red blood cell values rise and the body's own hormone axis is suppressed.