GLP-1 Retatrutide
- Form
- Vial
- Sizes
- 5mg, 6mg, 10mg, 12mg, 15mg, 20mg, 24mg, 30mg, 40mg, 50mg, 60mg
- Price (10-pack)
- 160 - 816 EUR
- Class
- GLP-1
Product Comparison
Retatrutide vs Semaglutide
Pure GLP-1 (Semaglutide) versus tri-agonist (Retatrutide). Different generations, different mechanisms.
GLP-1 
GLP-1 Semaglutide
- Form
- Vial
- Sizes
- 5mg, 10mg, 15mg, 20mg, 30mg, 50mg
- Price (10-pack)
- 100 - 408 EUR
- Class
- GLP-1
By the numbers
Number of sizes Retatrutide: 11 Semaglutide: 6
Smallest size Retatrutide: 5 mg Semaglutide: 5 mg
Largest size Retatrutide: 60 mg Semaglutide: 50 mg
Price from (10-pack) Retatrutide: 160 EUR Semaglutide: 100 EUR
Price up to (10-pack) Retatrutide: 816 EUR Semaglutide: 408 EUR
Values from the sizes and catalogue prices on this page, without Express and discounts.
Half-life compared
How quickly do they break down?
Share left after one dose, calculated from the half-lives in the lexicon
Retatrutide~6 daysSemaglutide~7 days
Half-life = 50 %
Day 14 after the dose
Semaglutide25 %
Retatrutide19.8 %
| Product | Half-life | Day 7 | Day 14 | Day 28 |
|---|---|---|---|---|
| Semaglutide | ~7 days | 50 % | 25 % | 6.3 % |
| Retatrutide | ~6 days | 45 % | 19.8 % | 3.9 % |
Simplified model without an absorption phase, half-lives from the TPD lexicon.
Level
Level with regular doses
Each dose adds to what is left of the last one until a plateau forms. Values relative to the first dose, simplified model, no dosing information.
Retatrutide: one dose per week, 7 days between dosesLexicon: Once weekly (subcutaneous)
Peak 1.8×Trough 0.8×
Day 21 · 4. dose
1.73× of the first dose
1.73× of the first dose
Plateau
from Day 21
96 % of the plateau after dose 4
Peak
1.8×
of the first dose
Trough
0.8×
before the next dose
Semaglutide: one dose per week, 7 days between dosesLexicon: Once weekly (subcutaneous)
Peak 2×Trough 1×
Day 28 · 5. dose
1.94× of the first dose
1.94× of the first dose
Plateau
from Day 28
97 % of the plateau after dose 5
Peak
2×
of the first dose
Trough
1×
before the next dose
| Feature | Retatrutide | Semaglutide |
|---|---|---|
| Category | GLP-1 | GLP-1 |
| Subcategory | GLP-1 & Fat Loss | GLP-1 & Fat Loss |
| Form | Vial | Vial |
| Price range | 160 - 816 EUR | 100 - 408 EUR |
| GLP-1 | Yes | Yes |
Quick reference
What both have in common
- Same subcategory: GLP-1 & Fat Loss - addressed via overlapping mechanisms.
- Same main category: GLP-1 / GLP-1
This page is a high-level comparison for community discussion only. Refer to the linked detail pages for full descriptions, risk profiles and peer-reviewed studies. Not medical advice.
