Description
Chonluten (Glu-Asp-Gly) is a synthetic tripeptide of the Khavinson bioregulator class with tissue-specific action on the respiratory epithelium. The substance was developed at the St. Petersburg Institute for investigating age-related respiratory models, with focus on mucosal regeneration and epithelial gene expression.
Per study reports Chonluten modulates gene activity in pulmonary epithelial cells via the Khavinson epigenetic mechanism. Preclinical studies describe effects on mucociliary clearance, secretion patterns, and cell regeneration in bronchial tissue.
Compared to Bronchogen (also broncho-pulmonary), Chonluten has a slightly different action focus - more at the mucosal level, less at the bronchial smooth muscle. Both bioregulators are described in Russian research literature as complementary.
Typical application is subcutaneous in 10-20 day courses two to three times per year.
You can order Chonluten as lyophilized peptide in 10-pack at 20mg per vial.
This information is for research and educational purposes only. No medical recommendations.
Risks & Safety
Chonluten is classified as very mild in the available literature and is among the most well tolerated compounds of the Khavinson class. In the available preclinical and limited human studies, no relevant toxic effects have been documented.
Observed in research and reports:
- Injection site: mild redness or transient irritation with subcutaneous use is the most common observation. The tripeptide itself is considered low-reactivity.
- Very thin human data: the data base consists almost entirely of small, Russian-language studies from the Khavinson environment. Independent peer-reviewed replication and robust long-term safety data on respiratory use are absent.
- Course-based pattern: the use described occurs in short 10-20 day courses. No data exist on the safety profile of continuous administration.
This classification does not replace medical advice. Risk and responsibility for any actual use lie entirely with the buyer.
Studies
- Peptide Regulation of Gene Expression and Protein Synthesis in Bronchial Epithelium - Lung 2014, Khavinson et al: mechanism paper on short-peptide action in bronchial epithelium, directly relevant to the Chonluten target tissue.
- Peptide bioregulators: A new class of geroprotectors. Message 1: Results of experimental studies - Advances in Gerontology 2013, Khavinson et al: experimental results across the bioregulator class with tissue-specific endpoints.
- Peptide Regulation of Gene Expression: A Systematic Review - Molecules 2021, Khavinson et al: review of tissue-specific Khavinson peptides.
- Peptide bioregulation of aging: results and prospects - Biogerontology 2010, Anisimov and Khavinson: aging mechanism review of the bioregulator class.
