Description
PTD-DBM is a synthetic peptide that blocks the CXXC5-Dishevelled interaction and thereby activates the Wnt/beta-catenin signaling pathway. The substance was developed by Korean research teams with primary research focus on hair follicle regeneration in alopecia models.
Per study reports PTD-DBM blocks negative Wnt regulation by CXXC5. Wnt activation in the hair follicle bulge is one of the central pathways for the anagen phase of the hair cycle - activation in research models shows stimulation of follicle neogenesis and accelerated wound healing in skin models.
A landmark publication in Journal of Investigative Dermatology 2017 documented topical PTD-DBM application in mice with dramatic hair regeneration in alopecic areas. The substance is now a young but exciting compound in the recreational community for hair restoration.
Typical application is topical (microneedling setup) - injection or systemic application isn’t established in research literature.
You can order PTD-DBM as lyophilized peptide in 10-pack at 5mg per vial.
This information is for research and educational purposes only. No medical recommendations.
Risks & Safety
PTD-DBM is a young compound applied primarily topically. Systemic exposure is low with topical application, but the overall data is thin.
Observed in the literature and user reports:
- Local skin reactions: with topical application, particularly in combination with microneedling, redness, irritation or transient sensitivity of the treated skin areas is the most common observation.
- Wnt pathway activation: the compound activates the Wnt/beta-catenin signaling pathway. This pathway is broadly involved in cell proliferation. The longer-term effects of repeated local activation are not conclusively characterized in the literature.
- Application route: injection or systemic application is not established in the research literature, so there is no data basis for non-topical routes.
- No long-term data: robust human studies exist only to a limited extent. The profile rests on a small number of dermatological studies and anecdotal experience.
This classification does not replace medical advice. Risk and responsibility for any actual use lie entirely with the buyer.
Studies
- Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis - Journal of Investigative Dermatology 2017, Lee et al: hair regeneration study with PTD-DBM in topical application.
- The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing - Journal of Experimental Medicine 2015, Lee et al: CXXC5 as a negative Wnt regulator in cutaneous wound healing.
- CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation - Cell Death and Differentiation 2015, Kim et al: characterization of the CXXC5 negative-feedback function in the Wnt/β-catenin pathway.
- Blockade of CXXC5-dishevelled interaction inhibits adipogenic differentiation, obesity, and insulin resistance in mice - Scientific Reports 2022, Seo et al: extended mechanistic characterization of the CXXC5-Dishevelled axis.
