Description
Adamax is a synthetic peptide with adamantane modification, developed for research applications in nootropic and neuroprotective setups. The adamantane group lends the compound elevated lipophilicity and thereby improved blood-brain barrier penetration.
Per study reports Adamax acts via modulation of cholinergic and glutamatergic pathways in the CNS. Preclinical studies describe effects on learning and memory performance in animal aging models and neuroprotection in oxidative stress models.
The substance is relatively young and less well characterized than classical nootropics like Selank or Semax. Specific data on Adamax is limited.
Pharmacokinetically lipophilic due to adamantane modification with improved CNS availability. Half-life relatively long.
This variant is a ready-to-use nasal spray: 10mg of Adamax dissolved in 5 ml saline and 0.4 ml bacteriostatic water (5.4 ml in total), nothing to mix yourself. One spray (0.1 ml) delivers about 185 mcg. A bottle lasts for about 50 sprays. It is made fresh once you place your order and ships as an express item. As a powder for reconstitution, Adamax remains available in vials.
This information is for research and educational purposes only. No medical recommendations.
Risks & Safety
Adamax is described as well tolerated per study reports. The substance is relatively young and considerably less well characterized than classical nootropics like Selank or Semax.
Observed in research and user reports:
- Nasal lining: the spray adds local effects: brief burning or tingling, an urge to sneeze, a runny nose and a bitter taste in the throat when solution runs down the back. With frequent use a dry lining or slight nosebleeds are possible.
- Neuronal modulation: Adamax acts in preclinical models via cholinergic and glutamatergic pathways, a biologically active intervention in central neurotransmitter systems.
- Adamantane modification: the adamantane group increases lipophilicity and CNS penetration and extends half-life, which prolongs the effect but reduces controllability.
- Thin data base: the specific data on Adamax is limited. Robust human studies and long-term data do not exist.
This classification does not replace medical advice. Risk and responsibility for any actual use lie entirely with the buyer.
Studies
- Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice - FEBS Letters 2010, Li et al: adamantane-modified neurotrophic peptides improve learning and memory and promote neurogenesis and synaptic plasticity in a mouse model.
- Transcriptomic response of rat hippocampus and spleen cells to single and chronic administration of the peptide selank - Doklady Biochemistry and Biophysics 2010, Kolomin et al: Selank effect on gene expression in hippocampus and spleen, evidence for GABAergic and neurosignaling-modulating pathways.
- Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats - Behavioural Neurology 2017, Kasian et al: Selank potentiates the anxiolytic action of diazepam in the chronic stress model.
- Rapid and slow response during treatment of generalized anxiety disorder with peptide anxiolytic selank - European Psychiatry 2012, Syunyakov et al: clinical Selank study on anxiolysis in generalized anxiety disorder.
- Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats - Bulletin of Experimental Biology and Medicine 2019, Kolik et al: BDNF regulation and memory protection by Selank in a rat model.
