Description
Testagen (Lys-Glu-Asp) is a synthetic tripeptide of the Khavinson bioregulator class with tissue-specific action on the male reproductive system, particularly testicular function. The substance was developed at the St. Petersburg Institute for investigating age-related testicular function changes.
Per study reports Testagen modulates gene expression in Leydig cells and Sertoli cells via the Khavinson epigenetic mechanism. Preclinical studies describe effects on steroidogenesis, spermatogenesis markers and age-related testicular aging indicators.
In Russian research literature Testagen is described in andrological aging setups, often as supportive compound to TRT research. International replication is limited.
Typical application is subcutaneous in 10-20 day courses two to three times per year.
You can order Testagen as lyophilized peptide in 10-pack at 20mg per vial.
This information is for research and educational purposes only. No medical recommendations.
Risks & Safety
Testagen is classified as very mild in the available literature and is among the most well tolerated compounds of the Khavinson bioregulator class. In the available preclinical and limited human studies, no relevant toxic effects have been documented.
Observed in research and reports:
- Injection site: mild redness or transient irritation with subcutaneous use is the most common observation. The tripeptide itself is considered low-reactivity.
- Very thin human data: the data base consists almost entirely of small, Russian-language studies from the Khavinson environment. International replication is limited. Robust long-term data on andrological use do not exist.
- Course-based pattern: the use described occurs in short 10-20 day courses. No data exist on the safety profile of continuous administration.
This classification does not replace medical advice. Risk and responsibility for any actual use lie entirely with the buyer.
Studies
- Peptide Regulation of Aging: 35-Year Research Experience - Bulletin of Experimental Biology and Medicine 2009, Khavinson and Anisimov: long-term review of tissue-specific tetrapeptides including testicular Khavinson bioregulators in aging models.
- Peptide bioregulation of aging: results and prospects - Biogerontology 2009, Anisimov and Khavinson: overview of Khavinson bioregulators with documented action on reproductive and endocrine markers.
- Peptide bioregulators: A new class of geroprotectors. Message 1: Results of experimental studies - Advances in Gerontology 2013, Khavinson, Kuznik and Ryzhak: experimental data on Khavinson bioregulators across multiple organ systems including testicular tissue.
- Peptides (Epigenetic Regulators) in the Structure of Rodents with a Long and Short Lifespan - Bulletin of Experimental Biology and Medicine 2017, Khavinson, Kormilets and Mar’yanovich: mechanism of epigenetic peptide regulation as the basis of tetrapeptide action in gonads.
