This information is for research and educational purposes only. No medical recommendations. Products are not approved for human use. For health questions, consult a doctor.

Lexicon

Sexual function

Alprostadil

Prostaglandin E1 for treating erectile dysfunction, a clinically established but delicate agent with sensitive use.

2 min read 1 sources Updated May 2026
Class
Prostaglandin E1 (vasodilator)
Use
Local (medical), 20mcg vials
Purpose
Erectile dysfunction
Status
Clinically established (medical)

What is Alprostadil?

Alprostadil is the medical form of prostaglandin E1 (PGE1), a vessel-widening messenger. It is a clinically established agent for treating erectile dysfunction and is prescribed for that indication. We carry it as pre-filled 20mcg vials.

Important: alprostadil is a medical agent with sensitive use. The classic application (intracavernosal injection) is a medically guided procedure, not a casual research experiment.

How it works

Alprostadil widens the blood vessels and relaxes the smooth muscle. Applied locally it increases circulation and can so trigger an erection, independent of sexual stimulation. That is exactly what makes it an effective agent for erectile dysfunction when tablets (like sildenafil/tadalafil) are not enough.

Use

Medical use is local and a medically guided procedure. Because of the delicate application and the risk of complications, medical supervision is the right way here, not a self-experiment.

  • Pre-filled 20mcg vials.
  • With uncertainty or first use, definitely seek medical advice.

Dosing

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What the research shows

A clinical study (Linet, NEJM 1996) showed that intracavernosal alprostadil was effective in men with erectile dysfunction with tolerable side effects and a clear dose-response relationship. So alprostadil is a well-evidenced, medically established agent, the sensitive application is the decisive point.

Side effects

  • Painful prolonged erection (priapism), an emergency that must be treated medically.
  • Pain or burning at the application site.
  • Dizziness, drop in blood pressure.

Practice

  • A delicate, medically applied agent, not a casual self-experiment.
  • With an erection lasting more than a few hours, seek medical help immediately (priapism).
  • For erection problems oral agents (sildenafil/tadalafil) are the first, simpler choice.

Storage

Store cool and protected from light, out of reach of children. Keep the original packaging closed and mind the expiry date.

Evidence

Sources

  1. 1 Efficacy and safety of intracavernosal alprostadil in erectile dysfunction (clinical study). Linet et al., New England Journal of Medicine, 1996

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Sizes, prices and availability for research use. Straight from the lexicon to the product page.

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