What is NA-Selank-Amidate?
NA-Selank-Amidate is a chemically stabilized form of selank, an anxiolytic peptide from Russian research. The added acetyl and the amidation make the molecule more resistant to breakdown, so it acts somewhat more reliably and longer than plain selank.
The appeal of selank: anxiolytic, but without the strong sedation and dependence potential of classic tranquilizers.
Comparison
Selank and its relatives in the lexicon
Selank in different forms and the related Semax, as described in the TPD lexicon. Tap a card to open its entry.
How it works
Selank acts on the GABA system and on the balance of various messengers and also influences the expression of genes around anxiety regulation. It calms and stabilizes without strong drowsiness.
The amidated variant is more stable in the body, which makes the effect more predictable.
Where it acts
Where Selank acted in studies
Tap a point or a card. All from studies with Selank, not with the NA form.
Known targets6
Compound PubChem CID 11765600 (Selank): one described target, Positive allosteric, more GABA binding to rat brain membranes. Which subunit is not clear.
- Gene
- GABRA1
- UniProt
- P14867
- ChEMBL
- CHEMBL2093872
- Action
- Positive allosteric, more GABA binding to rat brain membranes. Which subunit is not clear
Use (nasal or subcutaneous)
Dosing
Dosing
Dosing, titration and syringe
Loading the dosing information …
- Getting started and stepping up, drawn as a staircase
- Units on the U-100 syringe for every step
- How long one vial lasts
What the research shows
A clinical study (Zozulya, 2008) compared selank in generalized anxiety with a classic tranquilizer and found comparable anxiolytic effect without the typical sedation. The GABAergic mechanism is described preclinically (Frontiers, 2017). Most research comes from Russia.
Study results
What the trials measured
Interactive: switch tabs, tap points, show or hide arms. Arms are named relative to each other, no dosing advice.
How large the clinical studies were13
Number of participants per group, studies with Selank (not with the NA form)
The abstracts give no measured values on the effect. According to Zozulya 2008 Selank had an anxiolytic effect similar to medazepam, plus an effect against exhaustion. According to Medvedev 2015 phenazepam worked faster with Selank and its unwanted effects were smaller. Both studies come from Russia and are not in any international registry.
Genes with altered activity in the brain4
Number of 84 studied neurotransmission genes, rat cortex
Measured in rats, compared with untreated animals. In human nerve cells in culture (IMR-32), by contrast, Selank alone changed none of the genes, only together with GABA or olanzapine.
Research status
Where the research stands
Neither Selank nor the NA form is listed on ClinicalTrials.gov. The clinical studies on Selank come from Russia and are only published as journal articles. As of 26 Oct 2026. 10
- Preclinical Animal studies and cell cultures with Selank
- Phase 1 no registered trial
- Phase 2 no registered trial
- Phase 3 no registered trial
- Approval not yet
So far there is no registered trial in humans. 10
Side effects
- Generally well tolerated, occasionally mild irritation of the nasal mucosa (nasal).
- Rarely headache or grogginess.
- Local reactions with subcutaneous use.
Storage
Before mixing the powder is robust, normal room temperature (around 20 to 25 degrees) is fine, ideally kept in the dark. After mixing, keep in the fridge (2 to 8 degrees), do not freeze. It stays good there for at least 4 to 6 months with barely any loss of potency, in practice considerably longer. Swirl or shake to mix, both are fine.
Shelf life
How long it keeps
Robust, no fridge needed.
At least 4 to 6 months with barely any loss of potency.
- Keep it dark
- Dissolved: 2 to 8 degrees
- Note the mixing date on the vial
