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Lexicon
Bioregulators

Prostamax

A Khavinson cytogen peptide aimed at the prostate.

3 min read 7 sources

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Prostamax vial with white powder and the black TPD label on a white podium with a glowing ring, next to a short molecule model of blue and white spheres, a microscope in the background
No registered trial · not approved

Summary

At a glance

Sources checked on 26 Oct 2026

Length
4 amino acids

Lys-Glu-Asp-Pro, a cytogen from the Khavinson programme7

More chromatid exchanges
~2 -fold

12.0 instead of 5.9 per cell, blood cells of people aged 75 to 86 in the lab3

Human trials in the registry
0 trials

no trial with Prostamax on ClinicalTrials.gov, as of 26 Oct 20266

  • Prostamax is the tetrapeptide Lys-Glu-Asp-Pro from the Russian Khavinson programme of tissue-specific bioregulators.71
  • It is meant to target the prostate. So far only lab experiments on blood cells of very old people are documented, no data on the prostate itself.23
  • There it loosened densely packed genetic material: the number of exchanges between sister chromatids rose from 5.9 to 12.0 per cell.3
  • A computer analysis from the same research line considers transport into the cell via amino acid and peptide transporters possible.5
  • No approval and no registered human trial. Everything here is preclinical research, not a recommendation.61
Profile

Updated May 2026

Class
Short bioregulator peptide

Khavinson cytogen

Use
Subcutaneous

in mg

Target tissue
the prostate
Status
Data mostly from the Khavinson program
Sizes
20 mg

1 size in the shop

Contents 15 sections
  1. At a glance
  2. What is Prostamax?
  3. How it works
  4. What you need
  5. Reconstitution
  6. Dosing
  7. Injection
  8. What the research shows
  9. Research status
  10. Side effects
  11. Storage
  12. Related compounds
  13. FAQ
  14. Glossary
  15. Sources

What is Prostamax?

Prostamax is a short peptide from the Russian Khavinson program, which deals with tissue-specific bioregulators. These very short peptides (usually 2 to 4 amino acids) are meant to act specifically on a particular tissue, Prostamax is aimed at the prostate.

Up front: most research comes from a single research line and mostly from Russia, large independent studies are missing.

Comparison

Short peptides from the Khavinson programme

Prostamax next to other cytogens, as described in the TPD lexicon. Tap a card to open its entry.

Cytogen, prostate Prostamax Bioregulator
Cytogen, testes Testagen Bioregulator Cytogen, vessels Vesugen Bioregulator Tetrapeptide, pineal gland Epitalon Bioregulator

1

How it works

The theory behind the Khavinson peptides: they are meant to act at the level of gene regulation and restart age-related declining functions of a tissue. For Prostamax a supportive effect on the prostate is described.

How well this concept transfers to humans is little established outside the originating research.

Where it acts

Where Prostamax acted in experiments

Tap a point or a card. Grey = observed, no receptor is known. No data on the prostate itself.

  1. Blood cells (lymphocytes)

    Densely packed genetic material loosened, ribosome genes more active (lab)2

    Observed in trials
  2. Uptake into cells

    Transport via LAT1, LAT2 and PEPT1 possible on calculation (computer model)5

    Observed in trials
Cluster of glass cells each holding a glowing DNA double helix, small blue beads streaming into the cells from three molecule models at the edges
The idea of gene regulation, not shown in tissue. Symbolic image.

What you need

Supplies

2 things, numbered as in the picture

Tick off what you already have. Vial and BAC water are our real shop photos at the same size.

Prostamax vial and bacteriostatic water at the same size with the black TPD label, next to two U-100 insulin syringes, two alcohol swabs and a sharps container with a blue lid

  1. Prostamax vial

    The vial (lyophilized powder, usually 20mg).

    In the shop

  2. Water and supplies

    Bacteriostatic water, U-100 insulin syringes, alcohol swabs.

    In the shop

Reconstitution

Use the peptide calculator. A 20mg vial with 2ml water gives 10mg per ml. Just add the water to the vial and let it dissolve.

Step by step

Dissolving the powder

Four steps, the same for every vial size.

  1. 1Wipe the cap

    Clean the rubber stopper with an alcohol swab.

  2. 2Add BAC water

    Just add it, it does not matter if it hits the powder directly.

  3. 3Swirl or shake

    Until everything has dissolved, both are fine.

  4. 4Draw up

    With the U-100 insulin syringe.

Less water higher concentration fewer units on the syringe Example: 20 mg + 2 ml = 10 mg/ml

Dosing

Dosing

Dosing, titration and syringe

Loading the dosing information …

  • Getting started and stepping up, drawn as a staircase
  • Units on the U-100 syringe for every step
  • How long one vial lasts

Injection

The injection is subcutaneous, into the fat layer under the skin. Common spots are the abdomen (keep about two finger-widths clear of the navel), the front and the inner side of the thigh, or the back of the upper arm.

The short version:

Injection

Where and at what angle

Pick a spot or switch the angle. Subcutaneous means: into the fat layer, not the muscle.

Rotate the spot each time, never the same one twice in a row.

90°More fat under the skin

Rule of thumb: where there is more fat under the skin, insert straight at 90 degrees. In lean people with little fat, 45 degrees, so the needle stays in the fat layer. Simplified diagram.

  1. Clean the spot with an alcohol swab and let it dry

  2. Pinch up a small fold of skin

  3. Insert the needle: at 90 degrees where there is more fat under the skin, at 45 degrees in lean people with little fat

  4. Inject slowly, wait a moment, then withdraw

  5. Put the needle straight into the sharps container

Rotate the site each time so the tissue does not get irritated. Never the same spot twice in a row.

What the research shows

The Khavinson program has published numerous works on tissue-specific bioregulators over decades (overview: Khavinson, 2002), including effects on organ function and, in animal models, on lifespan. But the read must stay honest: the data come mostly from one research line, large independent studies are missing.

Study results

What the trials measured

Interactive: switch tabs, tap points, show or hide arms. Arms are named relative to each other, no dosing advice.

Genetic material in blood cells of older people3

Mean per cell, blood cells of people aged 75 to 86 in the lab

Sister chromatid exchanges3
Without Prostamax (comparison) 5.9%
With Prostamax 12.0%
Active ribosome genes (Ag-NOR)3
Without Prostamax (comparison) 1.0%
With Prostamax 2.5%

Values according to the abstract (Russian article). The authors read both as a loosening of genetic material. Whether this leads to any effect in the body or on the prostate has not been tested.

Frosted glass model of the bladder and prostate on a metal stand, on a white lab bench between racks of blue sample tubes
So far only lab experiments on blood cells. Symbolic image.

Research status

Where the research stands

From lab experiments on blood cells to computer models: what has been published on Prostamax. There is no registered human trial. As of 26 Oct 2026. 6

  1. Preclinical Blood cells in the lab and computer models
  2. Phase 1 no registered trial
  3. Phase 2 no registered trial
  4. Phase 3 no registered trial
  5. Approval not yet
Not approved and no registered human trial. The papers come almost entirely from the circle of the St. Petersburg Institute of Bioregulation and Gerontology.6

So far there is no registered trial in humans. 6

Side effects

  • Well tolerated in the available reports, mainly local reactions.
  • Solid, independent human safety data are limited.

Storage

Before mixing the powder is robust, normal room temperature (around 20 to 25 degrees) is fine, ideally kept in the dark. After mixing, keep in the fridge (2 to 8 degrees), do not freeze. It stays good there for at least 4 to 6 months with barely any loss of potency, in practice considerably longer. Swirl or shake to mix, both are fine.

Shelf life

How long it keeps

Undissolved (powder) Room temperature, around 20 to 25 degrees, dark

Robust, no fridge needed. Keeps for several months without trouble.

Dissolved (mixed) Fridge, 2 to 8 degrees, do not freeze

At least 4 to 6 months with barely any loss of potency. The bacteriostatic water brings a preservative.

  • Keep it dark
  • Dissolved: 2 to 8 degrees
  • Note the mixing date on the vial
Nine vials with white powder and blue caps in the door shelf of a bright fridge
Powder dark at room temperature, once dissolved into the fridge (2 to 8 degrees), stable there for at least 4 to 6 months. Symbolic image.

Related

Related compounds

Same groups: all in the TPD lexicon.

Prostamax
Testagen Khavinson cytogen related to the testes Vesugen Cytogen for the vessels Epitalon Tetrapeptide of the pineal gland Livagen Cytogen for the liver, in the same blood cell study Cortagen Cytogen for the brain cortex, in the same blood cell study Vilon Dipeptide, in the same blood cell study

FAQ

Common questions about Prostamax

Short answers, each backed by the sources below.

Is Prostamax approved or studied in humans?

No. There is no approval and as of 26 October 2026 no trial with Prostamax in the registry ClinicalTrials.gov. The published papers are lab experiments on blood cells and computer models.6

Where does Prostamax come from?

From Vladimir Khavinson's programme of tissue-specific bioregulators. First came extracts from animal tissue, including the prostate. Synthetic short peptides such as Lys-Glu-Asp-Pro were designed after that.17

Are there data on the prostate?

Not for synthetic Prostamax. The programme review mentions clinical observations with extracts from prostate tissue, but those are multi-component mixtures, not this tetrapeptide. For Prostamax itself there are only papers on blood cells.12

What was measured in blood cells?

In blood cells of people aged 75 to 86 sister chromatid exchanges rose from 5.9 to 12.0 per cell, active ribosome genes from 0.95 to 2.5. Another paper found slightly changed packing of the genetic material. The authors read this as loosening of regions that condensed with age.342

How is such a short peptide supposed to enter the cell?

That is unresolved. A computer analysis by the same research group calculates good binding of Lys-Glu-Asp-Pro to the transporters LAT1, LAT2 and PEPT1. It has not been measured.5

Which side effects are known?

There are no solid data because Prostamax has never been tested in a registered human trial. The entry mainly lists local reactions at the injection site, independent safety data are missing.6

Glossary

Terms explained briefly

Dotted words in the text open these explanations directly.

Bioregulator
Term from the Khavinson programme for peptides meant to act specifically on one tissue. The evidence comes mainly from tissue cultures and animal experiments.
Chromatin
The genetic material in the cell nucleus together with its packaging proteins. Densely packed regions are hardly read.
Cytogen
Synthetic short peptide of two to four amino acids, designed from the composition of a tissue extract.
Gene regulation
Control of which genes in a cell are read and how strongly. The Khavinson peptides are meant to act here, which is shown only in the lab.
Khavinson programme
Decades of research by Vladimir Khavinson's group in St. Petersburg on peptide extracts and short peptides for single tissues.
Lyophilisate
Freeze-dried powder. Without water a peptide keeps much longer.
Preclinical
Research before first use in humans, in cell cultures and animal models. Results cannot be transferred directly to humans.
Prostate
Male gland below the bladder. It produces part of the seminal fluid.
Subcutaneous
Into the fat layer just under the skin.
Tetrapeptide
A chain of exactly four amino acids. For Prostamax lysine, glutamic acid, aspartic acid and proline.

Evidence

Sources

Show all 7 sourcesHide sources 2 Studies1 Trial registry4 Database checked 26 Oct 2026

Studies

  1. Short peptides and genetic material in blood cells of older people

    Khavinson et al., Bulletin of Experimental Biology and Medicine, 2004

    DOI 10.1023/b:bebm.0000024393.40560.05 PMID 15085253
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  2. Transport of short peptides into the cell, computer analysis

    Khavinson et al., Biomolecules, 2023

    DOI 10.3390/biom13030552 PMID 36979488
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed

Trial registry

  1. Search on ClinicalTrials.gov (no trial with Prostamax)

    ClinicalTrials.gov, U.S. National Library of Medicine

    Checked 26 Oct 2026 via ClinicalTrials.gov API v2

Database

  1. Review: peptides and ageing, the Khavinson programme (PubMed record)

    Khavinson, Neuro Endocrinology Letters, 2002 (ohne DOI)

    PMID 12374906
    Checked 26 Oct 2026 via PubMed
  2. Prostamax and chromosomes in blood cells of older people (PubMed record)

    Dzhokhadze et al., Georgian Medical News, 2012 (russisch, ohne DOI)

    PMID 23221144
    Checked 26 Oct 2026 via PubMed
  3. Prostamax and the packing of genetic material in lymphocytes (PubMed record)

    Meskhi et al., Biofizika, 2004 (russisch, ohne DOI)

    PMID 15612551
    Checked 26 Oct 2026 via PubMed
  4. Structure of Prostamax in PubChem

    PubChem, U.S. National Library of Medicine (CID 9848296)

    Checked 26 Oct 2026 via PubChem

In the shop

Prostamax in the catalog

Sizes, prices and shipping times are on the product page.

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