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Regeneration

BPC + TB Blend

The classic among healing stacks: BPC-157 and TB-500 in one vial, two complementary repair routes.

2 min read 15 sources

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Still from the explainer video about this entry
BPC-157 only in phase 1 · not approvedLab tested in the shop

No time to read it all? The video sums up the whole entry in about a minute, from how it works to the studies and storage.

Summary

At a glance

Sources checked on 26 Oct 2026

On the ready-made blend
0 trials

no registered trial with BPC-157 and TB-500 together, as of 26 Oct 202614

Only study with both
32 rats

Achilles tendon, the combination added no benefit2

Wound closure after 7 days
+61 %

thymosin beta-4 in rats with skin wounds, against saline4

All human studies on BPC-157
30 people

three small studies without a control group12

  • The blend combines BPC-157, a peptide from gastric juice, with TB-500, which is regarded as a fragment of thymosin beta-4. There is no study on the ready-made blend.141
  • The only study of both together tested Achilles tendon healing in 32 rats. Each on its own was linked to better tissue, TB-500 more clearly, the combination added no benefit.2
  • In animal studies BPC-157 promoted new blood vessels via VEGFR2, thymosin beta-4 sped up wound closure in rats by up to 61 percent.84
  • In humans there are three small studies on BPC-157 with 30 people in total. 40 healthy people tolerated thymosin beta-4 into a vein without serious side effects.126
  • Neither component is approved. Everything here is the state of research, not a recommendation.1510
Profile

Updated May 2026

Class
Healing blend

BPC-157 + TB-500

Use
Subcutaneous

in mg, half/half

Ratio
half each

5+5 or 10+10

WADA
Banned

peptides

Sizes
10 to 30 mg

3 sizes in the shop

Contents 15 sections
  1. At a glance
  2. What is the BPC + TB Blend?
  3. How it works
  4. What you need
  5. Reconstitution
  6. Dosing
  7. Injection
  8. What the research shows
  9. Research status
  10. Side effects
  11. Storage
  12. Related compounds
  13. FAQ
  14. Glossary
  15. Sources

What is the BPC + TB Blend?

The BPC + TB Blend combines two of the best-known regeneration peptides in one vial: BPC-157 and TB-500 (thymosin beta-4). You also find both individually in the lexicon. It is probably the most common healing stack in the scene.

The 10mg vial holds half of each (5mg BPC + 5mg TB), the 20mg vial accordingly 10+10.

Comparison

BPC-157 and TB-500 alone and blended

The blend next to the single compounds and the three-way blend with KPV, as stated in the TPD lexicon. Tap a card to open its entry.

Blend of two peptides BPC + TB Blend BPC-157 TB-500 KPV 2 of 3 compounds
Single compound BPC-157 BPC-157 TB-500 KPV 1 of 3 compounds Single compound TB-500 (Thymosin Beta-4) BPC-157 TB-500 KPV 1 of 3 compounds Blend with KPV BPC + TB + KPV Blend BPC-157 TB-500 KPV 3 of 3 compounds

Simplified: in the only study of both together (rats) the combination added no benefit over either alone. 2

How it works

The two peptides act at different points of healing: BPC-157 acts more on the structural repair of connective tissue (tendons, ligaments, gastrointestinal tract), TB-500 more on cell migration and new vessel formation. Together they cover different phases of the healing cascade.

The mechanisms in detail are in the individual entries for BPC-157 and TB-500.

Where it acts

Components and where they act

Tap a point or a card. Colour = component. Almost all sites from animal studies on the single compound.

  1. Achilles tendon

    Better tendon tissue on their own, above all with TB-500, no added benefit together (rats)2

    BPC-157TB-500
  2. Skin and wounds

    Thymosin beta-4 sped up wound closure by up to 61 percent (rats)4

    TB-500
  3. Blood vessels

    BPC-157 promoted new vessels via VEGFR2 (cells and rats)8

    BPC-157
  4. Stomach and gut

    BPC-157 protected the mucosa and closed fistulas (rats)9

    BPC-157
  5. Heart

    Thymosin beta-4 was given into a vein in phase 2 after heart attack (registry)13

    Observed in trials

Known targets8

Compound CHEMBL4297358: two described targets, type of action on each card.

VEGF receptor 2 (BPC-157)
Gene
KDR
UniProt
P35968
ChEMBL
CHEMBL279
Action
Increased and activated in vessel cells, no proof of direct binding
Actin (thymosin beta-4)
Gene
ACTB
UniProt
P60709
ChEMBL
CHEMBL2062353
Action
Thymosin beta-4 binds free actin via the LKKTETQ motif (Philp 2003)
Translucent blue connective tissue fibres with cell nuclei and fine branching vessels, with a small and a large blue peptide structure on them
Two peptides, two targets. Symbolic image.

What you need

Supplies

2 things, numbered as in the picture

Tick off what you already have. Vial and BAC water are our real shop photos at the same size.

Vial of the BPC + TB Blend and bacteriostatic water at the same size with the black TPD label, next to two U-100 insulin syringes, two alcohol swabs and a sharps container with a blue lid

  1. Blend vial

    The blend vial (lyophilized powder, both compounds).

    In the shop

  2. Water and supplies

    Bacteriostatic water, U-100 insulin syringes, alcohol swabs.

    In the shop

Reconstitution

Use the peptide calculator. The values refer to the total amount in the vial. A 10mg vial with 2ml water gives 5mg per ml, 0.5mg total is then 10 units on the U-100 syringe. Just add the water to the vial and let it dissolve.

Step by step

Dissolving the powder

Four steps, the same for every vial size.

  1. 1Wipe the cap

    Clean the rubber stopper with an alcohol swab.

  2. 2Add BAC water

    Just add it, it does not matter if it hits the powder directly.

  3. 3Swirl or shake

    Until everything has dissolved, both are fine.

  4. 4Draw up

    With the U-100 insulin syringe.

Less water higher concentration fewer units on the syringe Example: 10 mg + 2 ml = 5 mg/ml

Dosing

Dosing

Dosing, titration and syringe

Loading the dosing information …

  • Getting started and stepping up, drawn as a staircase
  • Units on the U-100 syringe for every step
  • How long one vial lasts

Injection

The injection is subcutaneous, into the fat layer under the skin. Common spots are the abdomen (keep about two finger-widths clear of the navel), the front and the inner side of the thigh, or the back of the upper arm.

The short version:

Injection

Where and at what angle

Pick a spot or switch the angle. Subcutaneous means: into the fat layer, not the muscle.

Rotate the spot each time, never the same one twice in a row.

90°More fat under the skin

Rule of thumb: where there is more fat under the skin, insert straight at 90 degrees. In lean people with little fat, 45 degrees, so the needle stays in the fat layer. Simplified diagram.

  1. Clean the spot with an alcohol swab and let it dry

  2. Pinch up a small fold of skin

  3. Insert the needle: at 90 degrees where there is more fat under the skin, at 45 degrees in lean people with little fat

  4. Inject slowly, wait a moment, then withdraw

  5. Put the needle straight into the sharps container

Rotate the site each time so the tissue does not get irritated. Never the same spot twice in a row.

It is often injected near the affected region.

What the research shows

Both components are individually well described preclinically (thymosin beta-4: Crockford, 2010). For the fixed combination in humans there are no controlled studies, the benefit derives from the complementary mechanisms of the individual compounds. Honestly: this is experience- and mechanism-based, not study-proven for this exact mix.

Study results

What the trials measured

Interactive: switch tabs, tap points, show or hide arms. Arms are named relative to each other, no dosing advice.

Wound healing with thymosin beta-4 in rats4

More than in the saline control group, applied to the skin or into the abdominal cavity

New skin after 4 days4
Thymosin beta-4 (rats) 42%
New skin after 7 days4
Thymosin beta-4 (rats) 61%
Wound contraction after 7 days4
Thymosin beta-4 (rats) 11%

Study with full thymosin beta-4, not with the blend. The wounds also showed more collagen and more new vessels.

Where the knowledge on BPC-157 comes from11

Share of the 36 studies in a systematic review (literature up to June 2024)

Systematic review11 35 preclinical, 1 clinical study
Animal and cell studies 97.2%
Human studies 2.8%

The only human study in the review was a retrospective analysis of knee injections.

Participants by route12

All three published human studies on BPC-157 (review, search up to June 2026)

Knee pain, retrospective12
Into the knee 16%
Bladder inflammation, pilot study12
Into the bladder 12%
Safety, pilot study12
Into a vein 2%

None of the studies had a control group and none tested the blend with TB-500.

Anatomical model of a knee joint with bone, cartilage and ligaments on a lab bench, next to racks of sample tubes
There is no human study on the blend. Symbolic image.

Research status

Where the research stands

There is no study on the blend. Shown are registered trials on the single components. Thymosin beta-4 reached phase 3 as eye drops, which is not listed here. As of 26 Oct 2026. 13

  1. Preclinical Both together only in one rat study, without added benefit
  2. Phase 1 3 trials on components, 2 completed
  3. Phase 2 5 trials on components, 4 completed
  4. Phase 3 no registered trial
  5. Approval not yet
Not approved. ChEMBL lists BPC-157 with phase 1 and thymosin beta-4 with phase 3 (eye drops) as the highest phase, neither approved.15
Show all 6 trials on a timelineHide timeline 5 completed 1 running 0 with results
Phase 2
Without phase

Bar: start to primary endpoint (planned for running trials). Green = completed, blue = progress until 26 Oct 2026. Phase 1: 3 trials on safety and pharmacokinetics, not shown as bars.

Side effects

  • Generally well tolerated, mainly local reactions at the injection site.
  • Solid long-term human data are missing.
  • As with regenerative factors, a growth-promoting signal is theoretically critical with pre-existing growths.

Tolerability

Side effects in the human studies on BPC-157

Out of 100 participants, how many had a treatment-related side effect. Three small BPC-157 studies without placebo, none with the blend.

0 of 100 Participants
Event Participants
Treatment-related side effects12 0%

Zero does not mean safe here. 40 healthy people tolerated thymosin beta-4 into a vein without serious side effects. There are no data on the blend.126

Storage

Before mixing the powder is robust, normal room temperature (around 20 to 25 degrees) is fine, ideally kept in the dark. After mixing, keep in the fridge (2 to 8 degrees), do not freeze. It stays good there for at least 4 to 6 months with barely any loss of potency, in practice considerably longer. Swirl or shake to mix, both are fine.

Shelf life

How long it keeps

Undissolved (powder) Room temperature, around 20 to 25 degrees, dark

Robust, no fridge needed.

Dissolved (mixed) Fridge, 2 to 8 degrees, do not freeze

At least 4 to 6 months with barely any loss of potency. The bacteriostatic water brings a preservative.

  • Keep it dark
  • Dissolved: 2 to 8 degrees
  • Note the mixing date on the vial
Nine vials with white powder and blue caps in the door shelf of a bright fridge
Powder dark at room temperature, once dissolved into the fridge (2 to 8 degrees), stable there for at least 4 to 6 months. Symbolic image.

Related

Related compounds

Same compounds or blends with BPC + TB Blend: all in the TPD lexicon.

BPC + TB Blend
BPC-157 Main entry BPC-157 TB-500 (Thymosin Beta-4) Main entry TB-500 BPC-157 + TB-500 FRAG Blend Variant with the short fragment instead of TB-500 BPC + TB + KPV Blend The same components plus KPV BPC + TB Oral Blend The same components as a tablet Klow Blend Contains both plus GHK-Cu and KPV Glow Blend Contains both plus GHK-Cu

FAQ

Common questions about BPC + TB Blend

Short answers, each backed by the sources below.

Are there studies on the ready-made blend?

No. As of 26 October 2026 there is no trial with BPC-157 and TB-500 together on ClinicalTrials.gov. PubMed has one rat study on the Achilles tendon and three case reports on jaw nerve damage in which several peptides and other agents were given together. Cause and effect cannot be derived from them.1423

Do both work better together?

That is not established. In 32 rats with a repaired Achilles tendon each on its own was linked to better tendon tissue, significantly above all with TB-500, which also raised tensile strength. The combination gave no advantage over either alone. The authors suspect that both feed into the same signalling pathways.2

What is TB-500?

TB-500 is sold as a fragment of thymosin beta-4. Thymosin beta-4 is the main peptide that binds free actin in cells and is linked to cell migration, new vessel formation and tissue repair. A 2026 review finds hardly any solid human safety data for TB-500.17

How are the two components thought to work?

BPC-157 raised the receptor VEGFR2 and new vessel formation in vessel cells. Thymosin beta-4 carries its vessel-forming effect in its actin-binding motif and sped up wound healing in rats. Both come from cell and animal experiments.854

Which trials exist on the components?

Thymosin beta-4 was given into a vein in phase 2 after heart attack and tested earlier as a gel for pressure and leg ulcers, a third heart trial has been announced. For BPC-157 a phase 1 trial after shoulder surgery is planned, a study with gummies was completed without results.13

Which side effects are known?

None for the blend. No treatment-related side effects occurred in the three small human studies on BPC-157, but the certainty is very low. 40 healthy people tolerated thymosin beta-4 into a vein without serious side effects. One review warns of risks from unregulated manufacturing.12611

Glossary

Terms explained briefly

Dotted words in the text open these explanations directly.

Actin
Structural protein of the cell skeleton, needed for cell shape and movement.
Cell migration
Movement of cells to a wound or into new tissue, a basic step of healing.
Gastric juice
The acidic fluid in the stomach. BPC-157 was derived from a protective protein in it.
Lyophilisate
Freeze-dried powder. Without water a peptide keeps much longer.
New vessel formation
The formation of new small blood vessels, for example in healing tissue.
Preclinical
Research before first use in humans, in cell cultures and animal models.
Subcutaneous
Into the fat layer just under the skin.
Systematic review
An analysis of all studies on one question following fixed rules. Shows how much research there is and how good it is.
Thymosin beta-4
The body's own peptide of 43 amino acids that binds free actin in cells. TB-500 is regarded as a fragment of it.
VEGFR2
Receptor on vessel cells for the growth factor VEGF. It gives the start signal for new vessels.

Evidence

Sources

Show all 15 sourcesHide sources 11 Studies2 Trial registry2 Database checked 26 Oct 2026

Studies

  1. BPC-157, TB-500 and both together in Achilles tendon healing (rats)

    Biçer et al., Joint Diseases and Related Surgery, 2026

    DOI 10.52312/jdrs.2026.2951 PMID 42542926
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  2. Three case reports with peptides for jaw nerve injury

    Froum et al., Frontiers in Oral Health, 2026

    DOI 10.3389/froh.2026.1907109 PMID 42876687
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  3. Thymosin beta-4 accelerates wound healing (rats)

    Malinda et al., Journal of Investigative Dermatology, 1999

    DOI 10.1046/j.1523-1747.1999.00708.x PMID 10469335
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  4. The actin-binding site of thymosin beta-4 promotes angiogenesis

    Philp et al., The FASEB Journal, 2003

    DOI 10.1096/fj.03-0121fje PMID 14500546
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  5. Thymosin beta-4 into a vein in 40 healthy adults

    Ruff et al., Annals of the New York Academy of Sciences, 2010

    DOI 10.1111/j.1749-6632.2010.05474.x PMID 20536472
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  6. Review of approved and unapproved peptides in sport

    Mendias et al., Sports Medicine, 2026

    DOI 10.1007/s40279-026-02437-0 PMID 41966639
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  7. BPC-157 promotes new vessel formation via VEGFR2 (cells and rats)

    Hsieh et al., Journal of Molecular Medicine, 2017

    DOI 10.1007/s00109-016-1488-y PMID 27847966
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  8. Review of BPC-157 in the gastrointestinal tract

    Sikiric et al., Current Pharmaceutical Design, 2011

    DOI 10.2174/138161211796196954 PMID 21548867
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  9. Literature and patent review of BPC-157

    Józwiak et al., Pharmaceuticals, 2025

    DOI 10.3390/ph18020185 PMID 40005999
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  10. Systematic review of BPC-157 in orthopaedic sports medicine

    Vasireddi et al., HSS Journal, 2025

    DOI 10.1177/15563316251355551 PMID 40756949
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  11. Systematic review of all human studies on BPC-157

    Poolton et al., Acta Orthopaedica Belgica, 2026

    DOI 10.52628/92.3.15837 PMID 42885452
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed

Trial registry

  1. Trials on the components on ClinicalTrials.gov

    ClinicalTrials.gov, U.S. National Library of Medicine

    Checked 26 Oct 2026 via ClinicalTrials.gov API v2
  2. Registry search for both together (0 results)

    ClinicalTrials.gov, U.S. National Library of Medicine

    Checked 26 Oct 2026 via ClinicalTrials.gov API v2

Database

  1. Review of the structure and function of thymosin beta-4 (PubMed record)

    Crockford et al., Annals of the New York Academy of Sciences, 2010

    PMID 20536467
    Checked 26 Oct 2026 via PubMed, doi.org, Crossref
  2. BPC-157 and thymosin beta-4 in ChEMBL

    ChEMBL, EMBL-EBI (CHEMBL4297358, CHEMBL4594314)

    Checked 26 Oct 2026 via ChEMBL

In the shop

BPC + TB Blend in the catalog

Sizes, prices and shipping times are on the product page.

To the product