What is GHRP-2?
GHRP-2 (also pralmorelin) is a synthetic GH secretagogue from Cyril Bowers' research series. Like ghrelin it activates the GH secretagogue receptor and triggers a GH pulse. Compared with GHRP-6 it acts somewhat more strongly on GH release and drives appetite less, though the hunger effect is not gone.
How it works
GHRP-2 binds the ghrelin receptor (GHS-R1a) and through it triggers a pulsatile GH release. Combined with a GHRH analog like CJC-1295 without DAC, two signaling routes add up and the GH pulse is markedly higher.
The effect is saturable: above a certain dose (roughly 200 to 300mcg per shot) GH output barely rises further, higher doses mainly bring more side effects.
What you need
- The GHRP-2 vial (lyophilized powder).
- Bacteriostatic water, U-100 insulin syringes, alcohol swabs.
Reconstitution
Use the calculator above. A 5mg vial with 2ml water gives 2500mcg per ml, 100mcg is then 4 units on the U-100 syringe. Just add the water to the vial and let it dissolve.
Dosing
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Injection
Subcutaneous, fasted with a gap to meals. Disinfect the site, pinch a skin fold, rotate sites.
What the research shows
GHRP-2 is well studied: it raises GH dose-dependently and was even used in GH-deficient children. A study in healthy men (Laferrère, 2005) showed that GHRP-2, like ghrelin, increases food intake, the appetite effect to be aware of.
Side effects
- Increased appetite (via the ghrelin signal), weaker than GHRP-6.
- Water retention, tingling, briefly raised cortisol and prolactin at higher doses.
- Local reactions at the injection site.
Practice
- Strong as a GHRP partner to a GHRH analog.
- Stay low, the effect is saturated above 200 to 300mcg.
- Banned in official competition.
Storage
Before mixing the powder is robust, normal room temperature (around 20 to 25 degrees) is fine, ideally kept in the dark. After mixing, keep in the fridge (2 to 8 degrees), do not freeze. It stays good there for at least 8 to 10 weeks with barely any loss of potency, in practice considerably longer. Swirl or shake to mix, both are fine.