What is CJC-1295 without DAC?
CJC-1295 without DAC, also called Mod GRF 1-29, is a short-acting analog of the body's own GHRH (the hormone that triggers growth hormone release). Unlike the DAC variant it does not bind albumin long term but acts only briefly, with a clean, pulsatile GH rise.
That makes it the classic partner for a GHRP like Ipamorelin: the GHRH analog provides one signal, the GHRP the other, together a stronger pulse than either alone.
How it works
CJC-1295 without DAC docks at the GHRH receptor of the pituitary and triggers a short GH pulse there, similar to the natural rhythm. Because the effect fades quickly, the body's own pulse pattern stays intact.
Combined with a ghrelin mimetic (GHRP), two different signaling routes interlock and GH output is markedly higher than with either alone.
What you need
- The CJC-1295 vial (lyophilized powder).
- Bacteriostatic water for mixing.
- U-100 insulin syringes.
- Alcohol swabs and a clean workspace.
Reconstitution
Use the calculator above: pick vial size and water amount, it shows concentration and units per shot on the U-100 syringe.
A 5mg vial with 2ml water gives 2500mcg per ml, a 100mcg shot is then 4 units on the syringe. Just add the water to the vial and let it dissolve.
Dosing
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Injection
Subcutaneous into the subcutaneous fat with the short insulin needle.
- Ideally fasted, with some gap to meals, because carbs and fat dampen the GH pulse.
- Disinfect the site, pinch a skin fold, rotate injection sites.
What the research shows
The pharmacology of the CJC-1295 family was studied in healthy adults (Ionescu & Frohman, 2006): GHRH analogs raise GH and IGF-1 while the natural pulse pattern stays intact. The DAC variant acts for days, the form without DAC described here only briefly.
For the short-acting variant, most comes from GHRH-analog research and the practice of pairing it with GHRPs, no standalone approval exists.
Side effects
- Water retention, tingling, swollen hands, especially at higher GH levels.
- Redness or itching at the injection site.
- Tiredness or grogginess shortly after the injection (typical of the GH pulse).
Practice
- Useful as a GHRH partner to a GHRP, on its own the effect is weaker.
- Fasted and before sleep makes best use of the natural GH window.
- Banned in official competition.
Storage
Before mixing the powder is robust, normal room temperature (around 20 to 25 degrees) is fine, ideally kept in the dark. After mixing, keep in the fridge (2 to 8 degrees), do not freeze. It stays good there for at least 8 to 10 weeks with barely any loss of potency, in practice considerably longer. Swirl or shake to mix, both are fine.