What is CJC-1295 without DAC?
CJC-1295 without DAC, also called Mod GRF 1-29, is a short-acting analog of the body's own GHRH (the hormone that triggers growth hormone release). Unlike the DAC variant it does not bind albumin long term but acts only briefly, with a clean, pulsatile GH rise.
That makes it the classic partner for a GHRP like Ipamorelin: the GHRH analog provides one signal, the GHRP the other, together a stronger pulse than either alone.
Comparison
GHRH, ghrelin or the hormone itself
Where each compound acts, as stated in the TPD lexicon. Tap a card to open its entry.
How it works
CJC-1295 without DAC docks at the GHRH receptor of the pituitary and triggers a short GH pulse there, similar to the natural rhythm. Because the effect fades quickly, the body's own pulse pattern stays intact.
Combined with a ghrelin mimetic (GHRP), two different signaling routes interlock and GH output is markedly higher than with either alone.
Where it acts
Where CJC-1295 without DAC acts
Tap a point or a card. Colour = GHRH receptor. Derived from the backbone, without a study of its own.
- Pituitary
GHRH receptor, through which growth hormone release starts2
GHRH
Known targets2
One described target, Target of the GRF(1-29) backbone, like the body's own GHRH.
- Gene
- GHRHR
- UniProt
- Q02643
- ChEMBL
- CHEMBL2032
- Action
- Target of the GRF(1-29) backbone, like the body's own GHRH
What you need
Supplies
4 things, numbered as in the picture
Tick off what you already have. Vial and BAC water are our real shop photos at the same size.
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CJC-1295 vial
The CJC-1295 vial (lyophilized powder).
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Bacteriostatic water
Bacteriostatic water for mixing.
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U-100 insulin syringes
U-100 insulin syringes.
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Alcohol swabs
Alcohol swabs and a clean workspace.
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Reconstitution
Use the peptide calculator: pick vial size and water amount, it shows concentration and units per shot on the U-100 syringe.
A 5mg vial with 2ml water gives 2500mcg per ml, a 100mcg shot is then 4 units on the syringe. Just add the water to the vial and let it dissolve.
Step by step
Dissolving the powder
Four steps, the same for every vial size.
- 1Wipe the cap
Clean the rubber stopper with an alcohol swab.
- 2Add BAC water
Just add it, it does not matter if it hits the powder directly.
- 3Swirl or shake
Until everything has dissolved, both are fine.
- 4Draw up
With the U-100 insulin syringe.
Dosing
Dosing
Dosing, titration and syringe
Loading the dosing information …
- Getting started and stepping up, drawn as a staircase
- Units on the U-100 syringe for every step
- How long one vial lasts
Injection
The injection is subcutaneous, into the fat layer under the skin. Common spots are the abdomen (keep about two finger-widths clear of the navel), the front and the inner side of the thigh, or the back of the upper arm.
The short version:
Injection
Where and at what angle
Pick a spot or switch the angle. Subcutaneous means: into the fat layer, not the muscle.
Rotate the spot each time, never the same one twice in a row.
Rule of thumb: where there is more fat under the skin, insert straight at 90 degrees. In lean people with little fat, 45 degrees, so the needle stays in the fat layer. Simplified diagram.
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Clean the spot with an alcohol swab and let it dry
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Pinch up a small fold of skin
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Insert the needle: at 90 degrees where there is more fat under the skin, at 45 degrees in lean people with little fat
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Inject slowly, wait a moment, then withdraw
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Put the needle straight into the sharps container
Rotate the site each time so the tissue does not get irritated. Never the same spot twice in a row.
Use the short insulin needle, ideally fasted with some gap to meals, because carbs and fat dampen the GH pulse.
What the research shows
The pharmacology of the CJC-1295 family was studied in healthy adults (Ionescu & Frohman, 2006): GHRH analogs raise GH and IGF-1 while the natural pulse pattern stays intact. The DAC variant acts for days, the form without DAC described here only briefly.
For the short-acting variant, most comes from GHRH-analog research and the practice of pairing it with GHRPs, no standalone approval exists.
Research status
Where the research stands
No trial is registered for the version without DAC. The only registered CJC-1295 trial (phase 2, terminated early in 2006) used the DAC version and is listed in that entry. As of 26 Oct 2026. 6
- Preclinical Modified GRF(1-29) as the backbone, tested in rats only with the anchor
- Phase 1 no registered trial
- Phase 2 no registered trial
- Phase 3 no registered trial
- Approval not yet
So far there is no registered trial in humans. 6
Side effects
- Water retention, tingling, swollen hands, especially at higher GH levels.
- Redness or itching at the injection site.
- Tiredness or grogginess shortly after the injection (typical of the GH pulse).
Practice
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Useful as a GHRH partner to a GHRP, on its own the effect is weaker.
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Fasted and before sleep makes best use of the natural GH window.
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Banned in official competition.
Storage
Before mixing the powder is robust, normal room temperature (around 20 to 25 degrees) is fine, ideally kept in the dark. After mixing, keep in the fridge (2 to 8 degrees), do not freeze. It stays good there for at least 4 to 6 months with barely any loss of potency, in practice considerably longer. Swirl or shake to mix, both are fine.
Shelf life
How long it keeps
Robust, no fridge needed. Keeps for several months without trouble.
At least 4 to 6 months with barely any loss of potency. The bacteriostatic water brings a preservative.
- Keep it dark
- Dissolved: 2 to 8 degrees
- Note the mixing date on the vial
