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Lexicon
Hormones & growth

CP10 (CJC + IPA)

The standard GH stack: CJC-1295 (GHRH analog) plus ipamorelin (GHRP) in one vial, two signals for a stronger GH pulse.

3 min read 8 sources

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Still from the explainer video about this entry
No study of its own · not approvedLab tested in the shop

No time to read it all? The video sums up the whole entry in about a minute, from how it works to the studies and storage.

Summary

At a glance

Sources checked on 26 Oct 2026

Ipamorelin half-life
2 hours

after one infusion in 40 healthy men4

GH peak after ipamorelin
~40 minutes

a single pulse, peak after 0.67 hours, then a fall to barely measurable levels4

No cortisol rise
>200 -fold

ipamorelin at more than 200 times the effective amount without an ACTH or cortisol rise (pigs)3

Phase 3 in the registry
0 trials

no trial of the blend, ipamorelin alone up to phase 2, as of 26 Oct 20267

  • CP10 combines two peptides in one vial: CJC-1295 without DAC (a modified fragment of GHRH) and ipamorelin (a ghrelin mimetic). Both trigger the release of growth hormone, through two different receptors.36
  • That the two paths amplify each other was shown in a study in healthy men with GHRH and an older ghrelin mimetic: together they released more growth hormone than the sum of each alone.2
  • Ipamorelin is considered selective. In animal tests ACTH and cortisol did not rise even at more than 200 times the effective amount. In healthy men it triggered a single GH pulse, the half-life was 2 hours.34
  • In a phase 2 trial after bowel surgery ipamorelin was well tolerated but did not clearly shorten the time to the first meal.5
  • There is no study and no approval for the ready-made blend, CJC-1295 without DAC has no study of its own. Everything here is the state of research, not a recommendation.78
Profile

Updated May 2026

Class
GH stack

GHRH analog + GHRP

Use
Subcutaneous

in mcg/mg

Contents
CJC-1295 + ipamorelin
WADA
Banned

peptide hormones

Sizes
10 to 20 mg

2 sizes in the shop

Contents 15 sections
  1. At a glance
  2. What is CP10?
  3. How it works
  4. What you need
  5. Reconstitution
  6. Dosing
  7. Injection
  8. What the research shows
  9. Research status
  10. Side effects
  11. Storage
  12. Related compounds
  13. FAQ
  14. Glossary
  15. Sources

What is CP10?

CP10 is the standard combo stack for the growth hormone axis: CJC-1295 (a GHRH analog) and ipamorelin (a selective GHRP) in one vial. You also find both individually in the lexicon. The CP10 format simplifies the ready-mixed use.

The 10mg vial holds half of each (5+5), the 20mg vial 10+10.

Comparison

One path or two

Where each compound acts, as stated in the TPD lexicon. Tap a card to open its entry.

GHRH analogue, short CJC-1295 without DAC GHRH Ghrelin mimetic Ipamorelin Ghrelin GHRH analogue, long (DAC) CJC-1295 with DAC GHRH Blend with tesamorelin Tesa + Ipa Blend GHRHGhrelin
Blend, two paths CP10 (CJC + IPA) GHRHGhrelin

How it works

The two compounds engage two different systems of the GH axis: CJC-1295 the GHRH receptor, ipamorelin the ghrelin receptor. When both are activated at once, the GH pulse is markedly higher than with either alone, that is the point of the combination. Ipamorelin is selective, so without notable effect on cortisol or prolactin.

The individual mechanisms are in the lexicon entries for CJC-1295 and ipamorelin.

Where it acts

Where the two components act

Tap a point or a card. Colour = receptor, grey = observed in ipamorelin studies.

  1. Pituitary

    Two paths to growth hormone release, stronger together2

    GHRHGhrelin
  2. Gut

    Ipamorelin after bowel surgery: first meal tolerated earlier, difference not clear5

    Observed in trials

Known targets3

Compound CHEMBL58547 (Ipamorelin): two described targets, type of action on each card.

GHRH receptor
Gene
GHRHR
UniProt
Q02643
ChEMBL
CHEMBL2032
Action
Target of CJC-1295, like the body's own GHRH
Ghrelin receptor (GHSR)
Gene
GHSR
UniProt
Q92847
ChEMBL
CHEMBL4616
Action
Target of ipamorelin, acts via the GHRP receptor like GHRP-6
Glass pituitary gland with two docking sites, a blue molecule at each, glowing particles streaming down from both
Two receptors addressed at the same time, meant to trigger a stronger GH pulse. Symbolic image.

What you need

Supplies

2 things, numbered as in the picture

Tick off what you already have. Vial and BAC water are our real shop photos at the same size.

CP10 vial and bacteriostatic water at the same size with the black TPD label, next to two U-100 insulin syringes, two alcohol swabs and a sharps container with a blue lid

  1. CP10 vial

    The CP10 vial (lyophilized powder, both compounds).

    In the shop

  2. Water and supplies

    Bacteriostatic water, U-100 insulin syringes, alcohol swabs.

    In the shop

Reconstitution

Use the peptide calculator. The values refer to the total amount. A 10mg vial with 2ml water gives 5mg per ml, 0.2mg total is then 4 units on the U-100 syringe. Just add the water to the vial and let it dissolve.

Step by step

Dissolving the powder

Four steps, the same for every vial size.

  1. 1Wipe the cap

    Clean the rubber stopper with an alcohol swab.

  2. 2Add BAC water

    Just add it, it does not matter if it hits the powder directly.

  3. 3Swirl or shake

    Until everything has dissolved, both are fine.

  4. 4Draw up

    With the U-100 insulin syringe.

Less water higher concentration fewer units on the syringe Example: 10 mg + 2 ml = 5 mg/ml

Dosing

Dosing

Dosing, titration and syringe

Loading the dosing information …

  • Getting started and stepping up, drawn as a staircase
  • Units on the U-100 syringe for every step
  • How long one vial lasts
CP10 vial on a white bedside table with an insulin syringe and a closed notebook
Symbolic image.

Injection

The injection is subcutaneous, into the fat layer under the skin. Common spots are the abdomen (keep about two finger-widths clear of the navel), the front and the inner side of the thigh, or the back of the upper arm.

The short version:

Injection

Where and at what angle

Pick a spot or switch the angle. Subcutaneous means: into the fat layer, not the muscle.

Rotate the spot each time, never the same one twice in a row.

90°More fat under the skin

Rule of thumb: where there is more fat under the skin, insert straight at 90 degrees. In lean people with little fat, 45 degrees, so the needle stays in the fat layer. Simplified diagram.

  1. Clean the spot with an alcohol swab and let it dry

  2. Pinch up a small fold of skin

  3. Insert the needle: at 90 degrees where there is more fat under the skin, at 45 degrees in lean people with little fat

  4. Inject slowly, wait a moment, then withdraw

  5. Put the needle straight into the sharps container

Rotate the site each time so the tissue does not get irritated. Never the same spot twice in a row.

Ideally inject fasted before sleep.

What the research shows

The GHRH-analog pharmacology is studied in healthy people (Ionescu & Frohman, 2006). The combination of a GHRH analog and a GHRP gives a stronger GH pulse in practice than either alone. For the ready-mixed CP10 format itself there is no separate approval, the benefit derives from the individual compounds.

Study results

What the trials measured

Interactive: switch tabs, tap points, show or hide arms. Arms are named relative to each other, no dosing advice.

Time to the first tolerated meal5

Median in hours after bowel surgery, ipamorelin into a vein, 114 participants analysed

Phase 2 trial after bowel surgery5 up to 7 days, double-blind against placebo
Placebo 32.6 h
Ipamorelin alone 25.3 h

The difference was not statistically clear (p = 0.15) and the other endpoints did not differ either. The trial looked at gut motility rather than growth hormone. It used ipamorelin alone, not the blend.

Glass pituitary gland on a glass pedestal beneath a glass crescent moon, three empty petri dishes in front of it in a bright room
The single substances have been studied, the ready mix has no approval of its own. Symbolic image.

Research status

Where the research stands

There is no study of the blend. Shown are the registered trials of ipamorelin. CJC-1295 without DAC has none of its own, the only CJC-1295 trial used the DAC version. As of 26 Oct 2026. 7

  1. Preclinical Ipamorelin in cells, rats and pigs, the CJC backbone in rats
  2. Phase 1 no registered trial
  3. Phase 2 2 trials on components, 2 completed
  4. Phase 3 no registered trial
  5. Approval not yet
Not approved. ChEMBL lists ipamorelin with phase 2 as the highest phase, CJC-1295 without DAC has no study of its own and there is none on the blend.7
Show all 3 trials on a timelineHide timeline 2 completed 1 running 1 with results
Phase 2
Without phase

Bar: start to primary endpoint (planned for running trials). Green = completed, blue = progress until 26 Oct 2026.

Side effects

  • Water retention, tingling, swollen hands at higher GH levels.
  • Tiredness shortly after the injection (typical of the GH pulse).
  • Local reactions at the injection site.

Tolerability

Side effects in the phase 2 trial

Data on ipamorelin alone from a trial after bowel surgery, up to 7 days. There are no data on the CP10 blend.

95 of 100 Placebo
88 of 100 Ipamorelin alone
Event PlaceboIpamorelin alone
Any side effect5 95%88%

After abdominal surgery almost all participants have complaints, on placebo too. According to the trial ipamorelin was well tolerated. This cannot be transferred directly to injection under the skin or to the blend.5

Storage

Before mixing the powder is robust, normal room temperature (around 20 to 25 degrees) is fine, ideally kept in the dark. After mixing, keep in the fridge (2 to 8 degrees), do not freeze. It stays good there for at least 4 to 6 months with barely any loss of potency, in practice considerably longer. Swirl or shake to mix, both are fine.

Shelf life

How long it keeps

Undissolved (powder) Room temperature, around 20 to 25 degrees, dark

Robust, no fridge needed. Keeps for several months without trouble.

Dissolved (mixed) Fridge, 2 to 8 degrees, do not freeze

At least 4 to 6 months with barely any loss of potency. The bacteriostatic water brings a preservative.

  • Keep it dark
  • Dissolved: 2 to 8 degrees
  • Note the mixing date on the vial
Nine vials with white powder and blue caps in the door shelf of a bright fridge
Powder dark at room temperature, once dissolved into the fridge (2 to 8 degrees), stable there for at least 4 to 6 months. Symbolic image.

Related

Related compounds

Same receptors, blends with CP10 (CJC + IPA) or a different path: all in the TPD lexicon.

CP10 (CJC + IPA)
CJC-1295 without DAC Component: GHRH analogue without DAC Ipamorelin Component: selective ghrelin mimetic CJC-1295 with DAC Long version with albumin anchor Tesa + Ipa Blend Same idea with tesamorelin instead of CJC-1295 Sermorelin Unmodified GHRH fragment Tesamorelin GHRH analogue, approved in the US GHRP-2 Ghrelin receptor, also raises cortisol GHRP-6 Ghrelin receptor, also raises cortisol HGH 191AA (Somatropin) Growth hormone directly instead of via the pituitary

FAQ

Common questions about CP10 (CJC + IPA)

Short answers, each backed by the sources below.

What is in CP10?

Two peptides in equal parts in one vial: CJC-1295 (a modified fragment of GHRH) and ipamorelin (a ghrelin mimetic of five building blocks). According to the product text it is the short version without DAC. Both are in the lexicon on their own as well.63

Why two peptides together?

Because they act on the same release through two different receptors. In a study in 18 healthy men GHRH and the older ghrelin mimetic GHRP-6 together released more growth hormone than the sum of each alone. This has not been studied with CJC-1295 and ipamorelin themselves.2

Is CP10 approved or studied?

No. There is neither an approval nor a registered trial of the ready-made blend. Ipamorelin alone reached phase 2, as an infusion after bowel surgery. CJC-1295 without DAC has no study of its own, the studies under the name CJC-1295 tested the DAC version.785

What does it mean that ipamorelin is selective?

Older ghrelin mimetics such as GHRP-6 and GHRP-2 raise ACTH and cortisol as well as growth hormone. Ipamorelin did not do so in pigs, even at more than 200 times the effective amount. FSH, LH, prolactin and TSH stayed the same with all peptides tested.3

How does ipamorelin behave in humans?

In 40 healthy men an infusion triggered a single GH pulse. The peak came after about 40 minutes, then growth hormone fell to barely measurable levels. The half-life of ipamorelin was 2 hours and levels rose evenly with the dose.4

Which side effects are known?

There are no data on the blend. In the phase 2 trial with ipamorelin alone after bowel surgery 87.5 percent had any side effect versus 94.8 percent on placebo. The trial calls it well tolerated. The entry also lists the typical consequences of more growth hormone such as water retention and tingling.5

Glossary

Terms explained briefly

Dotted words in the text open these explanations directly.

Cortisol
Stress hormone of the adrenal gland, controlled by ACTH from the pituitary. Older GHRPs raise it as well, ipamorelin did not in animal tests.
Ghrelin receptor
Receptor (GHSR) on the pituitary that the hunger hormone ghrelin binds to. It is a second path to GH release besides the GHRH receptor.
GHRH
Growth hormone-releasing hormone: a hormone from the hypothalamus that prompts the pituitary to release growth hormone. An analogue is a synthetically modified version of it.
GHRP
Growth hormone-releasing peptide: short peptides such as ipamorelin or GHRP-6 that trigger growth hormone release via the ghrelin receptor.
Growth hormone (GH)
Pituitary hormone. It is released in pulses (mostly in deep sleep) and promotes fat breakdown and tissue build-up.
Half-life
Time after which only half of a substance is left in the blood. For ipamorelin about 2 hours.
Lyophilisate
Freeze-dried powder. Without water a peptide keeps much longer.
Placebo
Dummy preparation without active substance. Comparing against it shows what is due to the substance itself.
Prolactin
Pituitary hormone, among other things for milk production. Some GH peptides raise it as well.
Subcutaneous
Into the fat layer just under the skin.
WADA
World Anti-Doping Agency. Its prohibited list includes GH-releasing peptides among the peptide hormones.

Evidence

Sources

Show all 8 sourcesHide sources 6 Studies1 Trial registry1 Database checked 26 Oct 2026

Studies

  1. GH pulses under CJC-1295 (the DAC version was tested)

    Ionescu und Frohman, Journal of Clinical Endocrinology & Metabolism, 2006

    DOI 10.1210/jc.2006-1702 PMID 17018654
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  2. GHRH and GHRP-6 amplify each other (healthy men)

    Bowers et al., Journal of Clinical Endocrinology & Metabolism, 1990

    DOI 10.1210/jcem-70-4-975 PMID 2108187
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  3. Ipamorelin, the first selective GH secretagogue (cells, rats, pigs)

    Raun et al., European Journal of Endocrinology, 1998

    DOI 10.1530/eje.0.1390552 PMID 9849822
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  4. Ipamorelin in healthy men: half-life and GH pulse

    Gobburu et al., Pharmaceutical Research, 1999

    DOI 10.1023/a:1018955126402 PMID 10496658
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  5. Phase 2 trial of ipamorelin after bowel surgery

    Beck et al., International Journal of Colorectal Disease, 2014

    DOI 10.1007/s00384-014-2030-8 PMID 25331030 NCT00672074
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  6. Development of CJC-1295 from modified GRF(1-29) (rats)

    Jetté et al., Endocrinology, 2005

    DOI 10.1210/en.2004-1286 PMID 15817669
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed

Trial registry

  1. Ipamorelin trials on ClinicalTrials.gov (none on the blend)

    ClinicalTrials.gov, U.S. National Library of Medicine

    Checked 26 Oct 2026 via ClinicalTrials.gov API v2

Database

  1. Ipamorelin in ChEMBL (highest phase 2)

    ChEMBL, EMBL-EBI (CHEMBL58547)

    Checked 26 Oct 2026 via ChEMBL

In the shop

CP10 (CJC + IPA) in the catalog

Sizes, prices and shipping times are on the product page.

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