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Skin, hair & anti-aging

GGH (GHK + Glutathione + Histidine + NADH)

The premium anti-aging blend - four synergistic actives in one vial.

2 min read 11 sources

To the product To the sources
Glass vial with clear solution and a black TPD label on a white podium, next to it four different 3D molecules of blue, light blue, white and yellow spheres in a bright lab, symbolic image for GGH
No study of its own · not approved

Summary

At a glance

Sources checked on 26 Oct 2026

On the blend itself
0 studies

neither in the trial registry nor in PubMed, as of 25 Oct 20269

Wound closure with GHK-Cu gel
98.5 %

Median in diabetic foot ulcers, vehicle gel 60.8%, gel on the wound3

Glutathione infusion without protection
185 patients

Phase 3 trial: no protection against nerve damage from chemotherapy4

Skin lightening by infusion
37.5 %

only placebo study with intravenous glutathione, placebo 18.7%, not significant6

Response to NADH
31 %

26 people with chronic fatigue, oral NADH, placebo 8%8

  • GGH is a ready-made blend of GHK (copper tripeptide), glutathione, histidine and NADH in one vial. There is no study on the blend itself, neither in the registry nor in PubMed.910
  • GHK-Cu as a gel on diabetic foot ulcers closed the wounds by a median of 98.5 percent, on vehicle gel by 60.8 percent.3
  • Glutathione as an infusion did not protect against nerve damage from chemotherapy in a phase 3 trial with 185 cancer patients. In Parkinson's disease the difference from placebo was not significant.45
  • For skin lightening by infusion there is only one small placebo study without a significant difference, taken orally or as a cream glutathione lowered the melanin index in studies. Oral NADH helped 31 percent of people with chronic fatigue, placebo 8 percent.68
  • All data come from studies on single components, mostly given differently than under the skin. Everything here is the state of research, not a recommendation.11
Profile

Updated June 2026

Class
Anti-aging blend

4 actives

Use
Subcutaneous

2-3x per week

Size
10ml vial at 10mg/ml total active
Status
Research combination compound
Sizes
10 ml

1 size in the shop

Contents 14 sections
  1. At a glance
  2. What is GGH?
  3. What the four components do
  4. How to take it
  5. Dosing
  6. What GGH is researched for
  7. What the research shows
  8. Research status
  9. Side effects
  10. Storage
  11. Related compounds
  12. FAQ
  13. Glossary
  14. Sources

What is GGH?

GGH is a premium anti-aging blend combining four synergistic actives in a single vial: GHK (the copper tripeptide), glutathione (the body's master antioxidant), histidine (an essential amino acid with antioxidant function) and NADH (the reduced form of the energy coenzyme).

The idea: each active has a clear anti-aging effect on its own, in combination they complement each other. GHK stimulates collagen, glutathione neutralizes radicals, histidine protects cell membranes, NADH powers the mitochondria.

What the four components do

  • GHK (glycine-histidine-lysine): tripeptide with copper binding. Stimulates collagen synthesis, promotes skin regeneration and wound healing.
  • Glutathione: the body's most important antioxidant. Protects cells from oxidative stress, brightens skin, supports liver detox.
  • Histidine: essential amino acid. Forms histamine in the body, protects red blood cells from oxidative damage, anti-inflammatory.
  • NADH: the electron-rich form of NAD+. Drives the mitochondrial respiratory chain, raises cell energy.

Comparison

One component or four

Which GGH components each entry contains, as described in the TPD lexicon (GSH = glutathione, His = histidine). Tap a card to open its entry.

Ready-made blend GGH (GHK + Glutathione + Histidine + NADH) GHK GSH His NADH 4 of 4 components
Copper tripeptide alone GHK-Cu GHK GSH His NADH 1 of 4 components GHK without copper GHK Basic GHK GSH His NADH 1 of 4 components Glutathione alone Glutathione GHK GSH His NADH 1 of 4 components NAD+ instead of NADH NAD+ Inject GHK GSH His NADH 0 of 4 components

Simplified: more receptors does not automatically mean better, each path also brings its own effects.

Stacked sparkling glass layers like skin layers, next to them a glass mitochondrion and small blue, white and yellow 3D molecules
Four components with different targets, from the skin to the mitochondria. Symbolic image.

How to take it

Subcutaneous injection with an insulin needle, ideally in the abdomen (keep clear of the navel) or the front and inner side of the thigh.

  • Swirl or shake before each injection, both are fine.
  • Draw the desired amount with a U-100 insulin syringe.
  • 2-3x per week is enough thanks to cumulative effects across multiple mechanisms.

Topical use is theoretically possible but bioavailability is much worse than subcutaneous.

Glass vial with clear solution and a black TPD label, next to it a disposable syringe with a blue needle cap on a white lab bench
Ready-made solution, no reconstitution needed. Symbolic image.

Dosing

Dosing

Dosing, titration and syringe

Loading the dosing information …

  • Getting started and stepping up, drawn as a staircase
  • Units on the U-100 syringe for every step
  • How long one vial lasts

What GGH is researched for

  • Skin structure: the GHK portion stimulates collagen and elastin in the dermis.
  • Glow and brightening: glutathione is known for its skin-tone brightening effect.
  • Oxidative stress: the antioxidant components (glutathione, histidine) reduce systemic stress.
  • Cell energy: NADH improves mitochondrial function - some users report less fatigue.

Where it acts

Components and findings

Tap a point or a card. Colour = component (GSH = glutathione, His = histidine), data from studies on the single compound.

  1. Skin and wounds

    GHK-Cu gel: foot ulcers closed by a median of 98.5%3

    GHK
  2. Cells and liver

    Glutathione is the most abundant small thiol in the cell and protects against oxidative damage2

    GSH
  3. Brain (Parkinson's)

    Intravenous glutathione: no significant difference from placebo5

    GSH
  4. Fatigue

    Oral NADH: 31% responded, placebo 8%8

    NADH

What the research shows

The single actives each have solid data sets:

  • Pickart et al. 2015: comprehensive review on the molecular action of GHK-Cu on skin regeneration and anti-aging.
  • Forman et al. 2009: review of glutathione as the cell's most abundant low-molecular-weight thiol, protecting against oxidative damage and keeping redox balance.

Studies on the exact GGH blend don't exist - the combination is based on the logic of the single actions.

Study results

What the trials measured

Interactive: switch tabs, tap points, show or hide arms. Arms are named relative to each other, no dosing advice.

Wound closure in diabetic foot ulcers3

Median closed wound area, randomised trial with gel on the wound

All ulcers on the sole3
Placebo or vehicle gel +60.8%
GHK-Cu gel on the wound +98.5%
Large ulcers (over 100 mm²)3
Placebo or vehicle gel -10.3%
GHK-Cu gel on the wound +89.2%

Minus = the ulcer grew. Ulcer infections: 7 percent with GHK-Cu gel against 34 percent with vehicle gel. Gel on the skin, not an injection and not the blend.

Skin lightening with intravenous glutathione6

Share with lightening, the only placebo study according to a systematic review (16 people each)

Lightening6
Placebo or vehicle gel 18.7%
Intravenous glutathione 37.5%

Difference not significant (p = 0.054). The review considers infusions not indicated because of missing efficacy and side effects. In a phase 3 trial with 185 cancer patients glutathione infusions did not protect against nerve damage from chemotherapy.

NADH in chronic fatigue8

Share with good response, 26 people, placebo and NADH one after the other (crossover)

Good response8
Placebo or vehicle gel 8%
Oral NADH 31%

8 of 26 on NADH, 2 of 26 on placebo. Oral NADH, small pilot study without severe side effects.

Flat shimmering glass block with a copper-coloured edge on a bright lab shelf between petri dishes
Only the single components have been studied. Symbolic image.

Research status

Where the research stands

There is no study on the blend itself. Shown are registered trials with glutathione as an infusion; for GHK and NADH the registry only lists trials with gels, serums or capsules. As of 25 Oct 2026. 11

  1. Preclinical Cell and animal studies on the components
  2. Phase 1 no registered trial
  3. Phase 2 no registered trial
  4. Phase 3 1 trial on components, 1 completed
  5. Approval not yet
195 participants in phase 3 Not approved. The blend has neither been studied as a whole nor tested as a medicine.9
Show all 3 trials on a timelineHide timeline 3 completed 0 running 1 with results
Phase 3
Without phase

Bar: start to primary endpoint (planned for running trials). Green = completed, blue = progress until 25 Oct 2026.

Side effects

  • Skin redness: normal at the injection site for some hours.
  • Mild odor: typical for glutathione-containing solutions (sulfur note).
  • Very rare allergic reaction: start low, observe.

Storage

Refrigerate, protect from light. NADH is particularly light- and temperature-sensitive. Use within 4-6 weeks after opening.

Related

Related compounds

Same components or a different path: all in the TPD lexicon.

GGH (GHK + Glutathione + Histidine + NADH)
GHK-Cu The GHK component alone Glutathione The glutathione component alone GHK Basic GHK without bound copper Glow Blend Another blend with GHK-Cu NAD+ Inject NAD+ instead of NADH

FAQ

Common questions about GGH (GHK + Glutathione + Histidine + NADH)

Short answers, each backed by the sources below.

Are there studies on GGH?

No. There is no study on the ready-made blend, neither on ClinicalTrials.gov nor in PubMed (as of 25 October 2026). Only single components have been studied, mostly in another form: GHK as a gel, glutathione as an infusion, cream or capsule, NADH as a capsule.91011

What does research show on GHK?

GHK binds copper and acts on many skin regeneration pathways in cell and animal studies. In a randomised trial GHK-Cu gel closed diabetic foot ulcers by a median of 98.5 percent, vehicle gel by 60.8 percent; in large ulcers 89.2 against minus 10.3 percent. Infections occurred in 7 instead of 34 percent with the gel.13

Does glutathione as an injection lighten the skin?

That is not proven. Taken orally or as a cream glutathione lowered the melanin index in several randomised trials. For intravenous glutathione a systematic review found only one placebo study: 37.5 against 18.7 percent with lightening, not significant. The review therefore and because of side effects considers infusions not indicated, the Philippine drug authority issued a public warning. There is no study on use under the skin.67

What is known about glutathione infusions?

In a phase 3 trial with 185 cancer patients glutathione before chemotherapy did not protect against nerve damage, with weekly paclitaxel an acute pain syndrome was even milder on placebo. In a small Parkinson's trial with 21 people glutathione was well tolerated but mobility did not improve significantly more than on placebo.45

What does NADH do?

NADH is the energy-rich form of NAD+ and supplies electrons to the respiratory chain of the mitochondria. In a small study with 26 people with chronic fatigue 8 responded to NADH and 2 to placebo. Oral NADH was tested, not an injection.8

Which side effects have been described?

There are no data on the blend. Intravenous glutathione was well tolerated in the Parkinson's trial, nobody stopped because of side effects. Oral NADH showed no severe side effects. For skin lightening by infusion reviews report side effects that led to an official warning.587

Glossary

Terms explained briefly

Dotted words in the text open these explanations directly.

Collagen
Structural protein that gives skin, tendons and connective tissue their strength.
GHK
Tripeptide of glycine, histidine and lysine that binds copper. It occurs in the blood.
Glutathione (GSH)
Tripeptide made by the body and the most abundant small thiol in the cell. Neutralises reactive oxygen species.
Histidine
Essential amino acid. Among other things the body makes histamine from it.
Melanin
Skin pigment. In studies the melanin index is measured with a device on the skin.
Mitochondria
Power plants of the cell where ATP is made via the respiratory chain.
NADH
The reduced, energy-rich form of NAD+. It supplies electrons to the respiratory chain.
Oxidative stress
Too many reactive oxygen species for the cell's defences. They can damage proteins, fats and DNA.
Subcutaneous
Into the fat layer just under the skin.
U-100 syringe
Insulin syringe with 100 units per ml, one mark equals 0.01 ml.

Evidence

Sources

Show all 11 sourcesHide sources 8 Studies2 Trial registry1 Database checked 26 Oct 2026

Studies

  1. Review of GHK as a modulator of many skin regeneration pathways

    Pickart et al., BioMed Research International, 2015

    DOI 10.1155/2015/648108 PMID 26236730
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  2. Review of glutathione: protective roles, measurement and synthesis

    Forman et al., Molecular Aspects of Medicine, 2009

    DOI 10.1016/j.mam.2008.08.006 PMID 18796312
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  3. Randomised trial of GHK-Cu gel in diabetic foot ulcers

    Mulder et al., Wound Repair and Regeneration, 1994

    DOI 10.1046/j.1524-475X.1994.20406.x PMID 17147644
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  4. Phase 3: glutathione infusion against nerve damage from chemotherapy

    Leal et al., Cancer, 2014

    DOI 10.1002/cncr.28654 PMID 24619793 NCT02311907
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed, ClinicalTrials.gov (Studienkennung N08CA)
  5. Pilot trial: intravenous glutathione in Parkinson's disease

    Hauser et al., Movement Disorders, 2009

    DOI 10.1002/mds.22401 PMID 19230029
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  6. Systematic review: glutathione for skin lightening

    Sarkar et al., International Journal of Dermatology, 2025

    DOI 10.1111/ijd.17535 PMID 39444151
    Checked 26 Oct 2026 via doi.org, Crossref (Online-Jahr 2024), PubMed
  7. Review: glutathione for skin lightening, evidence and controversies

    Sonthalia et al., Indian Journal of Dermatology, Venereology and Leprology, 2016

    DOI 10.4103/0378-6323.179088 PMID 27088927
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  8. Oral NADH in chronic fatigue syndrome

    Forsyth et al., Annals of Allergy, Asthma and Immunology, 1999

    DOI 10.1016/S1081-1206(10)62595-1 PMID 10071523
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed

Trial registry

  1. Registry search for the blend (no trial)

    ClinicalTrials.gov, U.S. National Library of Medicine

    Checked 26 Oct 2026 via ClinicalTrials.gov API v2
  2. Trials on glutathione on ClinicalTrials.gov

    ClinicalTrials.gov, U.S. National Library of Medicine

    Checked 26 Oct 2026 via ClinicalTrials.gov API v2

Database

  1. PubMed search for the blend (0 results)

    PubMed, U.S. National Library of Medicine

    Checked 26 Oct 2026 via PubMed E-utilities

In the shop

GGH (GHK + Glutathione + Histidine + NADH) in the catalog

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