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Muscle & performance

17a-Methyl-1-Testosterone (M1T)

Extremely potent oral steroid - fast gains, but harsh sides and lethargy.

1 min read 10 sources

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White tablet bottle with a black TPD label on a white podium with a glowing ring, next to it a large blue 3D steroid molecule in front of a bright lab
No clinical trial · not approved

Summary

At a glance

Sources checked on 26 Oct 2026

On the trial registry
0 trials

No human trial with M1T on ClinicalTrials.gov, as of 26 Oct 20269

Named in the US steroid law
59 substances

M1T is one of them, controlled as an anabolic steroid in the USA since 20 January 20058

Creatinine in the case report
266 µmol/l

Previously 93, on M1T alongside ciclosporin, back to normal within one week of stopping3

Possible new metabolites
23 candidates

In the urine of healthy men after intake, doping research from 20255

  • M1T is 1-testosterone with a methyl group at carbon 17, chemically 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one. It was never approved as a medicine but was sold as a dietary supplement.101
  • In a yeast cell assay M1T strongly activated the androgen receptor. In rats the prostate and the levator ani muscle grew with the amount injected under the skin. Taken by mouth the weights stayed the same, but the prostate and calf muscle responded at the cellular level.1
  • A liver enzyme showed a strong effect in the liver, much stronger after swallowing than after injection. The authors see no selective action like that of a SARM but a possible liver risk.1
  • In humans there is one case report: on M1T alongside ciclosporin creatinine rose from 93 to 266 µmol/l and the liver marker ALT from 31 to 304 U/l. Within one week of stopping the values were normal.3
  • There is no registered trial and no approval. In the USA M1T has been controlled as an anabolic steroid since 2005 and it is banned in sport. Everything here is the state of research, not a recommendation.984
Profile

Updated June 2026

Class
Oral anabolic

17a-alkylated, highly potent

Use
Oral

1-2x per day

Half-life
short
WADA
banned

anabolic

Sizes
10 mg

1 size in the shop

Contents 12 sections
  1. At a glance
  2. What is M1T?
  3. How it works
  4. Use and dosing
  5. What the research shows
  6. Research status
  7. Side effects
  8. Storage
  9. Related compounds
  10. FAQ
  11. Glossary
  12. Sources

What is M1T?

M1T (17a-Methyl-1-Testosterone) is an extremely potent oral, 17a-alkylated steroid. It delivers fast, marked gains but comes with a harsh side effect profile - especially strong lethargy, poor well-being and high liver load. Many find the trade-off unfavorable.

This information is for research and educational purposes only. No medical advice.

Comparison

M1T and relatives

Related steroids at the androgen receptor, as described in the TPD lexicon. Tap a card to open its entry.

1-testosterone with a 17-methyl group, tablet 17a-Methyl-1-Testosterone (M1T) AR
1-testosterone without the methyl group, tablet DHB Oral (1-Testosterone) AR 1-testosterone as an injection DHB (Dihydroboldenone, 1-Testosterone Cypionate) AR Testosterone with a 17-methyl group Methyltestosterone AR

Simplified: M1T is 1-testosterone with a methyl group at position 17. With this group it also worked orally in animal tests and the authors see a possible liver risk in it. 1210

How it works

M1T activates the androgen receptor very strongly and does not aromatize. The high potency per mg makes it effective, but the central nervous side effects (lethargy, loss of appetite, malaise) and liver load are pronounced.

Where it acts

Where M1T acted in experiments

Tap a point or a card. Prostate, muscle and liver from rat studies, kidneys from a human case report.

  1. Prostate (rat)

    Grew with the amount injected under the skin, more cell division after swallowing1

    AR
  2. Muscle (rat)

    Levator ani muscle grew after injection, taken by mouth IGF-1 and androgen receptor changed in the calf muscle1

    AR
  3. Liver (rat)

    Strong effect on a liver enzyme, much stronger after swallowing1

    Observed in trials
  4. Kidneys (case report)

    Acute kidney injury on M1T alongside ciclosporin, normal within one week after stopping3

    Observed in trials

Known targets1

Compound PubChem CID 7092657: one described target, Strong activator in a yeast cell assay.

Androgen receptor
Gene
AR
UniProt
P10275
ChEMBL
CHEMBL1871
Action
Strong activator in a yeast cell assay
Two glossy blue 3D steroid molecules rest glowing on a transparent light blue fibre strand, behind them a fine network of glass nerve cells
M1T strongly activates the androgen receptor. Symbolic image.

Use and dosing

Dosing

Dosing, titration and syringe

Loading the dosing information …

  • Getting started and stepping up, drawn as a staircase
  • Units on the U-100 syringe for every step
  • How long one vial lasts
White tablet bottle with a black TPD label on a bright surface, four white tablets beside it
Tablet taken by mouth. Symbolic image.

What the research shows

As a designer/prohormone steroid there are hardly any controlled human studies. The AAS pharmacology (Kicman 2008, Hartgens & Kuipers 2004) classes the properties.

Study results

What the trials measured

Interactive: switch tabs, tap points, show or hide arms. Arms are named relative to each other, no dosing advice.

Kidney and bile marker in the case report3

One patient, values in µmol/l before M1T and on M1T alongside ciclosporin

Creatinine3 Kidney marker
Before 93 µmol/l
On M1T alongside ciclosporin 266 µmol/l
Bilirubin3 Bile pigment
Before 12 µmol/l
On M1T alongside ciclosporin 37 µmol/l

Single case, not a trial. The liver marker ALT rose from 31 to 304 U/l. After stopping M1T and ciclosporin kidney and liver values were normal within one week. The authors suspect that M1T slowed the breakdown of ciclosporin in the liver.

How little M1T shows up in urine4

Limits of a 2010 lab method in ng/ml of urine, smaller means more sensitive

Limit of detection4
Urine method from 2010 2 ng/ml
Limit of quantification4
Urine method from 2010 10 ng/ml

The method found M1T in a new oral product and identified positive urine samples. According to the paper M1T had been on the prohibited list since 2006.

Transparent glass model of a liver on a white lab bench, a small glass dumbbell in front of it, racks of blue-capped tubes at the sides
Rat studies point to a strong effect in the liver. Symbolic image.

Research status

Where the research stands

M1T has never been tested in a registered human trial. Doping laboratories have only studied what appears in urine after intake. As of 26 Oct 2026. 9

  1. Preclinical Yeast cell assay and rats (Hershberger assay)
  2. Phase 1 no registered trial
  3. Phase 2 no registered trial
  4. Phase 3 no registered trial
  5. Approval not yet
Never approved. In the USA M1T has been a Schedule III anabolic steroid by law since 20 January 2005 and it is on the banned list in sport.9

So far there is no registered trial in humans. 9

Side effects

  • Lethargy: pronounced - the main problem for many users.
  • Liver: 17a-alkylated, very strong - short cycles, liver support.
  • Lipids and blood pressure unfavorable.
  • HPTA suppression - PCT topic.

Storage

Store dry and cool, protected from light. Out of reach of children.

Three white tablet bottles and a folded light blue towel on a white shelf
Store dry, cool and protected from light. Symbolic image.

Related

Related compounds

Same receptors: all in the TPD lexicon.

17a-Methyl-1-Testosterone (M1T)
DHB Oral (1-Testosterone) 1-testosterone without the methyl group, oral DHB (Dihydroboldenone, 1-Testosterone Cypionate) 1-testosterone as an injection Methyltestosterone Testosterone with the same 17-methyl group Superdrol (Methasterone) Also 17-methylated, as a tablet Methylstenbolone Also a 17-methylated designer steroid Anadrol (Oxymetholone) Comparison compound in the metabolite study

FAQ

Common questions about 17a-Methyl-1-Testosterone (M1T)

Short answers, each backed by the sources below.

Are there studies in humans?

No, not a registered one. ClinicalTrials.gov lists no trial with M1T (as of 26 October 2026). In humans there is one case report plus work by doping laboratories that studied which metabolites appear in urine after intake. Everything here is the state of research, not a recommendation.931

How does M1T work?

It activates the androgen receptor. In a yeast cell assay M1T was a potent androgen. In rats it made the prostate and the levator ani muscle grow with the amount injected under the skin. Taken by mouth it did not change the weights but increased cell division in the prostate and altered IGF-1 and the androgen receptor in the calf muscle. The authors found no selective action like that of a SARM.1

How is M1T related to 1-testosterone?

M1T is a derivative of 1-testosterone that also works when swallowed: it carries an extra methyl group at carbon 17. 1-testosterone itself bound very selectively to the androgen receptor in cell experiments. In rats an equimolar amount was as potent as testosterone propionate on the prostate, seminal vesicles and levator ani muscle. Unlike with testosterone propionate, liver weight rose.3102

What is known about the liver and kidneys?

In rats a liver enzyme (tyrosine aminotransferase) showed a strong effect in the liver, much stronger after swallowing. In the case report a 29-year-old man took M1T alongside the drug ciclosporin: creatinine rose from 93 to 266 µmol/l, ALT from 31 to 304 U/l and bilirubin from 12 to 37 µmol/l. Within one week of stopping both the values were normal.13

Which side effects do reviews of anabolic steroids describe?

There are no frequencies for M1T itself. Reviews of anabolic steroids in general describe suppressed own testosterone production that can last for months, rising blood pressure and falling HDL cholesterol. In women there is a high risk of virilisation.76

How is M1T detected in sport?

Through urine. A method from 2010 detects M1T from 2 ng/ml. Besides M1T, doping laboratories found mainly two metabolites with a 17α-methyl group plus further ones whose excretion they followed over time. In 2025 a new measuring technique added 23 candidates for previously unknown metabolites.415

How is M1T classified legally?

Never approved as a medicine. In the USA the anabolic steroid law of 2004 names M1T as one of 59 substances and since 20 January 2005 it has been a controlled Schedule III anabolic steroid there. In sport it is on the banned list.84

Glossary

Terms explained briefly

Dotted words in the text open these explanations directly.

1-testosterone
Steroid with a double bond between the first and second carbon atoms, the parent compound of M1T.
17-alpha methyl group
Small carbon group at carbon 17 of the steroid. It slows breakdown in the liver so the compound also works when swallowed.
Androgen receptor
Protein inside the cell that testosterone and related steroids bind to. Genes are then read, for example for muscle building.
Ciclosporin
Drug that dampens the immune system. It is broken down in the liver and can damage the kidneys at too high levels.
Creatinine
Breakdown product from muscle that the kidneys excrete. If it rises in the blood the kidneys are working less well.
Hershberger assay
Standard test in castrated rats that measures how strongly a substance makes the prostate, seminal vesicles and a pelvic muscle grow.
Hormone axis (HPTA)
Hypothalamus, pituitary and testes together control the body's own testosterone production. Steroids from outside suppress this axis.
Levator ani muscle
Pelvic muscle of the rat that is particularly sensitive to androgens. It serves as a measure of anabolic effect.
M1T (methyl-1-testosterone)
Short name for 17α-methyl-1-testosterone, a synthetic steroid that was never approved as a medicine.
SARM
Selective androgen receptor modulator: ideally acts mainly on muscle and bone, less on the prostate and liver.
Schedule III
Level of US controlled substance law that includes anabolic steroids. Possession and trade are controlled.
Tyrosine aminotransferase
Liver enzyme whose amount shows how strongly a substance acts in the liver.

Evidence

Sources

Show all 10 sourcesHide sources 7 Studies2 Trial registry1 Database checked 26 Oct 2026

Studies

  1. M1T in a cell assay, in rats and metabolites in urine

    Parr et al., Endocrinology, 2011

    DOI 10.1210/en.2011-1164 PMID 21990312
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  2. 1-testosterone as a potent androgen with anabolic properties

    Friedel et al., Toxicology Letters, 2006

    DOI 10.1016/j.toxlet.2006.03.001 PMID 16621347
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  3. Acute kidney injury on M1T alongside ciclosporin, case report

    Al-Niaimi und Lyon, Dermatology and Therapy, 2013

    DOI 10.1007/s13555-013-0038-6 PMID 24281763
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed, PMC (Volltext)
  4. M1T in a new product and detection in urine

    Qiu et al., Chinese Journal of Chromatography, 2010

    DOI 10.3724/sp.j.1123.2010.00049 PMID 20458920
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  5. New metabolites of oxymetholone and M1T in urine

    Koomen et al., Journal of the American Society for Mass Spectrometry, 2025

    DOI 10.1021/jasms.5c00129 PMID 40702409
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  6. Review: pharmacology of anabolic steroids

    Kicman, British Journal of Pharmacology, 2008

    DOI 10.1038/bjp.2008.165 PMID 18500378
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  7. Review: effects and side effects of anabolic steroids in athletes

    Hartgens und Kuipers, Sports Medicine, 2004

    DOI 10.2165/00007256-200434080-00003 PMID 15248788
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed

Trial registry

  1. US Anabolic Steroid Control Act of 2004, M1T on the list (DEA)

    U.S. Drug Enforcement Administration, Federal Register 70 FR 74653, 2005

    Checked 26 Oct 2026 via Federal Register API
  2. Search on ClinicalTrials.gov (no trial)

    ClinicalTrials.gov, U.S. National Library of Medicine

    Checked 26 Oct 2026 via ClinicalTrials.gov API v2

Database

  1. Structure of M1T in PubChem

    PubChem, NCBI (CID 7092657)

    Checked 26 Oct 2026 via PubChem

In the shop

17a-Methyl-1-Testosterone (M1T) in the catalog

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