Superdrol (Methasterone)

No. ClinicalTrials.gov lists not a single trial with methasterone. In humans there are only case reports from people who had swallowed dietary supplements containing methasterone. Everything here is the state of research, not a recommendation.¹¹¹

In a series of 5 previously healthy people jaundice appeared 2 weeks after stopping, bilirubin peaked another 2 to 3 weeks after presentation and everything had healed about 12 weeks after presentation. In a review of 52 cases people saw a doctor at a median of 56 days after starting and bilirubin peaked 28 days after stopping. Nobody died or needed a new liver.¹²⁵

In the review of 52 liver injuries from steroids 43 percent also had kidney injury. Single case reports on methasterone describe severe bile congestion with kidney failure and IgA nephropathy.²⁴³

It binds the androgen receptor about as strongly as testosterone and strongly activates it in cell assays, with the effect lasting several days after exposure. It barely bound oestrogen, progesterone or cortisol receptors. The methyl groups at positions 2 and 17 are reported to hinder conversion to oestrogen.¹⁰⁶

Since 2002 new designer steroids such as methasterone have been sold as dietary supplements. By March 2010 the DEA counted 62 such products. In New York a lab later even found it in vitamin and mineral capsules whose buyers complained of hair loss, fatigue and muscle aches. The US drug agency sent a warning letter about one such product over health damage as early as 2006.⁷¹⁰⁶

There are no measurements of this for methasterone itself. Reviews of anabolic steroids in general describe a rise in blood pressure, a drop in HDL cholesterol and suppression of the body's own testosterone production that can last for months after stopping.⁹⁸

The compound is the same. The case reports and the animal data on the ratio of anabolic to androgenic effect concern the swallowed form. There are no data of its own on the oil form.¹⁰¹