The Peptide Desk The Peptide Desk

This information is for research and educational purposes only. No medical recommendations. Products are not approved for human use. For health questions, consult a doctor.

Lexicon
Mitochondria

SLU-PP-332 + BAM15 Combo

Two experimental metabolic compounds in one capsule: the ERR agonist SLU-PP-332 plus the mitochondrial uncoupler BAM15.

1 min read 10 sources

To the product To the sources
Two different glossy blue ring molecules above a white podium with a blue light ring, a few white capsules at the edge, symbolic image for the combination of SLU-PP-332 and BAM15
No study of its own · not approved

Summary

At a glance

Sources checked on 25 Oct 2026

On the combination
0 studies

neither in the trial registry nor in PubMed; no human trial of either component either, as of 25 Oct 20267

Longer running time (SLU-PP-332)
~70 %

Mice run to exhaustion on a treadmill, distance about 45 percent longer, SLU-PP-332 injected2

Half-maximal effect at ERRα
98 nM

Cell assay, 230 nM at ERRβ and 430 nM at ERRγ, so strongest at ERRα2

Body weight (BAM15)
-15 %

Mice on a high-fat diet after 5 weeks, almost only less fat, same food intake5

BAM15 orally available (mice)
67 %

Share reaching the blood after oral dosing, half-life 1.7 hours5

  • The capsule combines two experimental metabolic compounds: the ERR agonist SLU-PP-332 and the mitochondrial uncoupler BAM15.910
  • SLU-PP-332 activates the nuclear receptors ERRα, ERRβ and ERRγ and triggered a gene programme in mice like after endurance exercise. The animals ran about 70 percent longer.21
  • BAM15 lets energy dissipate as heat in the mitochondria. Mice on a high-fat diet lost fat with it, without eating more or losing lean mass.56
  • There is not a single study on the combination. Whether the two complement each other, interfere or add up their risks has not been studied.78
  • There is no human study for either compound. Everything here is preclinical research, not a recommendation.7
Profile

Updated May 2026

Class
Metabolic combo

ERR agonist + uncoupler

Use
Oral

capsule

Contents
SLU-PP-332 + BAM15
Status
Purely preclinical

no human data

Sizes
250 mcg

1 size in the shop

Contents 13 sections
  1. At a glance
  2. What is the SLU-PP-332 + BAM15 Combo?
  3. How it works
  4. How to take it
  5. Dosing
  6. What the research shows
  7. Research status
  8. Side effects
  9. Storage
  10. Related compounds
  11. FAQ
  12. Glossary
  13. Sources

What is the SLU-PP-332 + BAM15 Combo?

This combo combines two experimental metabolic compounds in one capsule: SLU-PP-332 (an ERR agonist, "exercise mimetic" candidate) and BAM15 (a mild mitochondrial uncoupler). You also find SLU-PP-332 individually in the lexicon. Both target increased energy expenditure.

Up front: both compounds are purely preclinical, there is no human data.

Comparison

Single or combined

The two components on their own and as a capsule, as stated in the TPD lexicon. Tap a card to open its entry.

ERR agonist SLU-PP-332 ERR Mitochondria 1 of 2 targets Mitochondrial uncoupler BAM15 ERR Mitochondria 1 of 2 targets
Both in one capsule SLU-PP-332 + BAM15 Combo ERR Mitochondria 2 of 2 targets

Simplified: two targets in one capsule does not mean twice the effect. There is no study on the combination. 8

How it works

SLU-PP-332 activates ERR receptors and switches on programs tied to endurance and fat burning. BAM15 mildly uncouples the mitochondria so that more energy is released as heat instead of ATP, which raises expenditure. Together they are meant to boost metabolism.

Details on SLU-PP-332 are in its own lexicon entry.

Where it acts

Components and where they act

Tap a point or a card. ERR = SLU-PP-332, mitochondria = BAM15. All from cell and mouse studies on the single compound.

  1. Skeletal muscle

    More endurance type IIa fibres, gene programme like after endurance exercise (SLU-PP-332, mice)2

    ERR
  2. Fat tissue

    Less fat mass in obesity, with each of the two compounds (mice)1

    ERRMitochondria
  3. Liver

    More fat breakdown, liver fat back to normal on a high-fat diet (BAM15, mice)5

    Mitochondria
  4. Heart

    Better pumping function in pressure-overload heart failure (SLU-PP-332, mice)3

    ERR
  5. Kidney

    Age-related protein loss in urine and inflammation reduced (SLU-PP-332, old mice)4

    ERR

Known targets2

Compound PubChem CID 5338394 (SLU-PP-332), 565708 (BAM15): three described targets, type of action on each card.

Estrogen-related receptor α (ERRα)
Gene
ESRRA
UniProt
P11474
ChEMBL
CHEMBL3429
Action
Agonist (SLU-PP-332), strongest effect
Estrogen-related receptor β (ERRβ)
Gene
ESRRB
UniProt
O95718
ChEMBL
CHEMBL3751
Action
Agonist (SLU-PP-332)
Estrogen-related receptor γ (ERRγ)
Gene
ESRRG
UniProt
P62508
ChEMBL
CHEMBL4245
Action
Agonist (SLU-PP-332), the most important one in the heart
Abstract glass muscle fibres with glowing mitochondria, one blue molecule switches on receptors in the cell nucleus while the other makes the mitochondria glow warmly
Two routes: genes for endurance and energy as heat. Symbolic image.

How to take it

Oral, one capsule with some water, rather during the day because of the activating effect.

Open white bottle with a few white capsules on a white tray next to a glass of water in morning light
Taken orally as a capsule with some water, as described in the entry. Symbolic image.

Dosing

Dosing

Dosing, titration and syringe

Loading the dosing information …

  • Getting started and stepping up, drawn as a staircase
  • Units on the U-100 syringe for every step
  • How long one vial lasts

What the research shows

SLU-PP-332 mildened metabolic syndrome in a mouse study (Billon, 2024). BAM15 is also known from preclinical metabolic research. For both there are no human studies, let alone for the fixed combination. This is clearly experimental, anyone needing proven dosing is at the wrong product.

Study results

What the trials measured

Interactive: switch tabs, tap points, show or hide arms. Arms are named relative to each other, no dosing advice.

Treadmill to exhaustion2

More than mice without compound, in percent (rounded values from the full text)

Running time2
Without compound (comparison) 0%
With SLU-PP-332 70%
Running distance2
Without compound (comparison) 0%
With SLU-PP-332 45%

SLU-PP-332 was injected into the abdominal cavity of the mice, not given as a capsule. In muscle the share of endurance type IIa fibres rose. Mouse model, not tested in humans.

Mice on a high-fat diet5

Change compared with mice without BAM15, in percent

Body weight5 after 5 weeks with BAM15 in the food
Without compound (comparison) 0%
With BAM15 -15%
Blood triglycerides5
Without compound (comparison) 0%
With BAM15 -29%
Free fatty acids in the liver5
Without compound (comparison) 0%
With BAM15 -42%

Values from the results section of the study (full text). Body temperature, lean mass and food intake stayed the same. Both tabs show separate studies on one component each, never the combination.

Lab bench with Petri dishes, culture flasks and test tubes, two small blue ring molecules hovering above
So far only cell and mouse studies on the single compounds. Symbolic image.

Research status

Where the research stands

There is no study on the combination. The registry also lists no human trial on the components SLU-PP-332 and BAM15. As of 25 Oct 2026. 7

  1. Preclinical Cell and mouse studies on each component
  2. Phase 1 no registered trial
  3. Phase 2 no registered trial
  4. Phase 3 no registered trial
  5. Approval not yet
Not approved, neither the combination nor any component. ChEMBL lists both compounds without a clinical phase.7

So far there is no registered trial in humans. 7

Side effects

  • Solid human data are missing for both components.
  • Mitochondrial uncouplers historically have a narrow safety window, so particular caution.
  • Start low and watch closely.

Storage

Store dry, cool and protected from light, out of reach of children. Keep the original container closed and mind the expiry date.

Three white capsule bottles on a bright shelf next to a folded light blue towel
Dry, cool and away from light, bottle closed. Symbolic image.

Related

Related compounds

Same targets or a different path: all in the TPD lexicon.

SLU-PP-332 + BAM15 Combo
SLU-PP-332 Component, single entry in the lexicon BAM15 Component, single entry in the lexicon DNP (2,4-dinitrophenol) Older uncoupler with a narrow safety window MOTS-c Peptide from the mitochondria, a different metabolic approach AICAR Activates the energy enzyme AMPK 5-Amino-1MQ Different metabolic approach (NNMT inhibitor)

FAQ

Common questions about SLU-PP-332 + BAM15 Combo

Short answers, each backed by the sources below.

Are there studies on the combination?

No. As of 25 October 2026 there is no study on the combination of SLU-PP-332 and BAM15, neither on ClinicalTrials.gov nor in PubMed. Each component on its own has also only been studied in cells and mice.87

What does SLU-PP-332 do?

SLU-PP-332 activates the three nuclear receptors ERRα, ERRβ and ERRγ, most strongly ERRα. In mice it switched on genes like a training session, the share of endurance muscle fibres rose and the animals ran about 70 percent longer. In obese mice energy use rose, fat mass increased less and insulin action improved.21

What does BAM15 do?

BAM15 is a mitochondrial uncoupler: protons flow back past ATP synthase and the energy is lost as heat. Unlike DNP it does not act on the outer cell membrane in cell experiments. Mice on a high-fat diet weighed 15 percent less after 5 weeks, at the same food intake and with unchanged body temperature.65

Why exactly these two together?

Both raised energy use in mice, by different routes: SLU-PP-332 via genes for endurance and fat burning, BAM15 directly at the mitochondria. Whether this adds up in one capsule has not been tested anywhere. It is just as open whether side effects add up.158

Do the compounds work by mouth at all?

For BAM15 yes, at least in mice: 67 percent of an oral dose reached the blood and the half-life was 1.7 hours. In the endurance study SLU-PP-332 was injected into the abdominal cavity. There are no data on absorption in humans for either compound.52

Which side effects are known?

There are no solid data because neither compound has been tested in humans. In mice body temperature, liver and kidney markers stayed normal with BAM15. Mitochondrial uncouplers have historically had a narrow safety window and mouse data cannot rule that out.75

Glossary

Terms explained briefly

Dotted words in the text open these explanations directly.

Agonist
A substance that activates a receptor, like a key that fits and turns the lock.
ATP
The energy currency of the cell. Mitochondria make it from fat and sugar.
ERR
Estrogen-related receptors α, β and γ. Nuclear receptors that control genes for mitochondria, fat burning and endurance. They share only their lineage with oestrogen itself.
Exercise mimetic
A substance that mimics parts of the effects of exercise in the body without training. So far a research term.
Metabolic syndrome
A combination of belly fat, high blood lipids, high blood sugar and high blood pressure.
Mitochondria
Power plants of the cell. Inside them fat and sugar are turned into energy using oxygen.
Mitochondrial uncoupler
A substance that separates energy release in the mitochondria from ATP production. The energy is lost as heat.
Nuclear receptor
A receptor inside the cell that directly switches genes on or off once activated.
Preclinical
Research before first use in humans, in cell cultures and animal models. Results cannot be transferred directly to humans.
Type IIa fibres
Muscle fibres that are fast but still work with endurance because they have many mitochondria.

Evidence

Sources

Show all 10 sourcesHide sources 6 Studies1 Trial registry3 Database checked 25 Oct 2026

Studies

  1. SLU-PP-332 in obesity and metabolic syndrome (mice)

    Billon et al., Journal of Pharmacology and Experimental Therapeutics, 2024

    DOI 10.1124/jpet.123.001733 PMID 37739806
    Checked 25 Oct 2026 via doi.org, Crossref, PubMed
  2. SLU-PP-332 as an ERR agonist and endurance in mice

    Billon et al., ACS Chemical Biology, 2023

    DOI 10.1021/acschembio.2c00720 PMID 36988910
    Checked 25 Oct 2026 via doi.org, Crossref, PubMed, PMC (Volltext)
  3. ERR agonists in heart failure (mice)

    Xu et al., Circulation, 2024

    DOI 10.1161/CIRCULATIONAHA.123.066542 PMID 37961903
    Checked 25 Oct 2026 via doi.org, Crossref, PubMed
  4. SLU-PP-332 and the ageing kidney (mice)

    Wang et al., American Journal of Pathology, 2023

    DOI 10.1016/j.ajpath.2023.07.008 PMID 37717940
    Checked 25 Oct 2026 via doi.org, Crossref, PubMed
  5. BAM15 reverses diet-induced obesity and insulin resistance in mice

    Alexopoulos et al., Nature Communications, 2020

    DOI 10.1038/s41467-020-16298-2 PMID 32409697
    Checked 25 Oct 2026 via doi.org, Crossref, PubMed, PMC (Volltext)
  6. First description of BAM15

    Kenwood et al., Molecular Metabolism, 2014

    DOI 10.1016/j.molmet.2013.11.005 PMID 24634817
    Checked 25 Oct 2026 via doi.org, Crossref, PubMed

Trial registry

  1. Search on ClinicalTrials.gov (no trial)

    ClinicalTrials.gov, U.S. National Library of Medicine

    Checked 25 Oct 2026 via ClinicalTrials.gov API v2

Database

  1. PubMed search for the combination (0 results)

    PubMed, U.S. National Library of Medicine

    Checked 25 Oct 2026 via PubMed E-utilities
  2. Structure of SLU-PP-332 in PubChem

    PubChem, U.S. National Library of Medicine (CID 5338394)

    Checked 25 Oct 2026 via PubChem
  3. Structure of BAM15 in PubChem

    PubChem, U.S. National Library of Medicine (CID 565708)

    Checked 25 Oct 2026 via PubChem

In the shop

SLU-PP-332 + BAM15 Combo in the catalog

Sizes, prices and shipping times are on the product page.

To the product