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Mitochondria

SLU-PP-332

An oral exercise-mimetic candidate (ERR agonist). Very new, purely preclinical, with no human data at all.

3 min read 7 sources

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Preclinical · not approvedLab tested in the shop

No time to read it all? The video sums up the whole entry in about a minute, from how it works to the studies and storage.

Summary

At a glance

Sources checked on 26 Oct 2026

In humans
0 trials

no registered trial, as of 26 Oct 20265

Targets
3 receptors

ERRα, ERRβ and ERRγ, strongest at ERRα in cell assays2

Longer running time (mice)
~70 %

to exhaustion on a treadmill, distance about 45% longer, compound injected2

Half-maximal effect at ERRα
98 nM

Cell assay, 230 nM at ERRβ and 430 nM at ERRγ2

  • SLU-PP-332 is a small synthetic molecule, not a peptide. It activates the nuclear receptors ERRα, ERRβ and ERRγ, most strongly ERRα.62
  • In mice it switched on a gene programme like after endurance exercise. The share of endurance muscle fibres rose, the animals ran about 70 percent longer.2
  • In obese mice energy use and fat burning rose, fat mass increased less and insulin action improved.1
  • Further mouse studies show effects on the heart and the ageing kidney. In the endurance study SLU-PP-332 was injected into the abdominal cavity, not given as a tablet.342
  • There are no studies in humans and no approval. Everything here is preclinical research, not a recommendation.57
Profile

Updated May 2026

Class
ERR agonist

exercise mimetic

Route
Oral

tablet

Status
Purely preclinical

no human data

Frequency
Daily

rather in the morning

Sizes
5 sizes

250mcg*100tabs, 500mcg*100tabs, 1mg*100tabs …

Contents 14 sections
  1. At a glance
  2. What is SLU-PP-332?
  3. How it works
  4. How to take it
  5. Dosing
  6. What the research shows
  7. Research status
  8. Side effects
  9. Practice
  10. Storage
  11. Related compounds
  12. FAQ
  13. Glossary
  14. Sources

What is SLU-PP-332?

SLU-PP-332 is not a peptide but a small synthetic molecule and a so-called exercise-mimetic candidate. The idea behind it: to trigger part of the metabolic signals that otherwise arise from endurance training, without actually training.

It acts as an agonist at the ERR receptors (estrogen-related receptors), which help control energy metabolism in the cell. SLU-PP-332 is very new, comes from basic research and is offered by us as an oral tablet. Honestly up front: there is no human data on it.

Comparison

Exercise mimetics in the lexicon

Substances listed as exercise mimics in the TPD lexicon, with their target as described there. Tap a card to open its entry.

ERR agonist SLU-PP-332 ERR
REV-ERB agonist SR9009 (Stenabolic) REV-ERB PPAR-delta agonist Cardarine (GW-501516) PPARδ AMPK activator AICAR AMPK

Simplified: different switches in energy metabolism. None of them replaces training, none is approved as a training substitute.

How it works

Via the ERR receptors, SLU-PP-332 activates programmes in cells related to endurance and fat burning: more energy expenditure, more fatty-acid oxidation, better mitochondrial activity. In mouse models this led to less fat mass and better insulin sensitivity, similar to a training effect.

Important: this is all described in cells and mice. Whether and how it translates to humans is simply not studied.

Where it acts

Where SLU-PP-332 acted in mouse studies

Tap a point or a card. Colour = ERR. All from cell and mouse studies.

  1. Skeletal muscle

    More endurance type IIa fibres, gene programme like after endurance exercise2

    ERR
  2. Fat tissue

    Less gain in fat mass in obesity, more fat burning1

    ERR
  3. Heart

    Better pumping function and less fibrosis in pressure-overload heart failure3

    ERR
  4. Kidney

    Age-related protein loss in urine and inflammation reduced, old mice4

    ERR

Known targets2

Compound PubChem CID 5338394: three described targets, type of action on each card.

Estrogen-related receptor α (ERRα)
Gene
ESRRA
UniProt
P11474
ChEMBL
CHEMBL3429
Action
Agonist, strongest effect (EC50 98 nM)
Estrogen-related receptor β (ERRβ)
Gene
ESRRB
UniProt
O95718
ChEMBL
CHEMBL3751
Action
Agonist (EC50 230 nM)
Estrogen-related receptor γ (ERRγ)
Gene
ESRRG
UniProt
P62508
ChEMBL
CHEMBL4245
Action
Agonist (EC50 430 nM), the most important one in the heart
Glass muscle fibres with glowing blue mitochondria, blue molecules docking onto receptors on top
Via ERR receptors SLU-PP-332 switches on genes for mitochondria and endurance. Symbolic image.

How to take it

SLU-PP-332 is offered by us as a tablet, so it is taken orally, no dissolving and no injecting.

  • One tablet a day, rather in the morning, because the effect is said to be activating.
  • With some water, with or without food.
  • Because it can be activating, rather not late in the evening.
White tablet bottle with the black TPD label, a few white tablets in front, a glass of water next to it
Sold as a tablet at TPD, injected in the studies. Symbolic image.

Dosing

Dosing

Dosing, titration and syringe

Loading the dosing information …

  • Getting started and stepping up, drawn as a staircase
  • Units on the U-100 syringe for every step
  • How long one vial lasts

What the research shows

There is a real, cleanly published study (Billon, 2024) in which SLU-PP-332 alleviated metabolic syndrome in mice, raised energy expenditure and fat burning and lowered fat mass. That is an interesting preclinical basis.

But that is all it is: there are no human studies, no long-term data and no approved product. SLU-PP-332 is clearly in the experimental zone. The study with a link is in the source block below.

Study results

What the trials measured

Interactive: switch tabs, tap points, show or hide arms. Arms are named relative to each other, no dosing advice.

Treadmill to exhaustion2

More than mice without compound, in percent (rounded values from the full text)

Running time2
Without compound (comparison) 0%
With SLU-PP-332 70%
Running distance2
Without compound (comparison) 0%
With SLU-PP-332 45%

Sedentary mice, injected into the abdominal cavity twice daily for 7 days. In muscle the share of endurance type IIa fibres rose, after 2 weeks grip strength did too. Mouse model, not tested in humans.

Half-maximal effect per receptor2

EC50 in nanomolar, lower means stronger

ERRα2
With SLU-PP-332 98 nM
ERRβ2
With SLU-PP-332 230 nM
ERRγ2
With SLU-PP-332 430 nM

Cell assay with full-length receptors. In the heart, according to a mouse study, ERRγ is mainly responsible for the effect.

Twisted bundle of glass muscle fibres and a glass running shoe on a white lab bench between sample racks
Endurance and muscle fibres, so far shown only in mice. Symbolic image.

Research status

Where the research stands

ClinicalTrials.gov lists no trial with SLU-PP-332. All data come from cell and mouse studies. As of 26 Oct 2026. 5

  1. Preclinical Cell assays and mouse models on endurance, obesity, heart and kidney
  2. Phase 1 no registered trial
  3. Phase 2 no registered trial
  4. Phase 3 no registered trial
  5. Approval not yet
Not approved. ChEMBL lists SLU-PP-332 without a clinical phase.5

So far there is no registered trial in humans. 5

Side effects

There is no solid human side-effect data, because there are no human studies. Little reliable can be derived from the animal data and the anecdotal level. That is exactly why more than for most others applies here: be careful, start low and when in doubt leave it alone until there is better data.

Practice

  1. Keep expectations low, the effects are described in mice, not in humans.

  2. Start very low and observe closely.

  3. Take rather in the morning, since likely activating.

  4. A real exercise mimetic does not replace training, at best it complements it.

White running shoes, a water bottle with a light blue lid and a light blue towel on a wooden bench

Storage

Store the tablets cool, dry and protected from light, out of reach of children. Keep the original packaging closed and mind the expiry date.

Three white tablet bottles on a bright shelf next to a folded light blue towel
Cool, dry and away from light. Symbolic image.

Related

Related compounds

Blends with SLU-PP-332 or a different path: all in the TPD lexicon.

SLU-PP-332
SLU-PP-332 + BAM15 Combo Contains SLU-PP-332 plus BAM15 BAM15 Different path: mitochondrial uncoupler SR9009 (Stenabolic) Different nuclear receptor: REV-ERB Cardarine (GW-501516) Different nuclear receptor: PPAR-delta AICAR Activates the energy enzyme AMPK MOTS-c Peptide from the mitochondria, metabolism

FAQ

Common questions about SLU-PP-332

Short answers, each backed by the sources below.

Are there studies in humans?

No. As of 26 October 2026 ClinicalTrials.gov lists no trial with SLU-PP-332 and ChEMBL lists it without a clinical phase. All data come from cell assays and mouse models.57

What does SLU-PP-332 do in the cell?

It activates the three nuclear receptors ERRα, ERRβ and ERRγ, most strongly ERRα. These receptors switch on genes for mitochondria and fat burning. In muscle cells mitochondrial function and cellular respiration rose.2

What did the mouse studies show?

Sedentary mice ran about 70 percent longer and 45 percent further after 7 days, the share of endurance muscle fibres rose. In obese mice energy use and fat burning rose, fat mass increased less and insulin action improved.21

Does it work as a tablet too?

That has not been studied. In the endurance study SLU-PP-332 was injected into the abdominal cavity, two hours later its level was higher in muscle than in blood. There are no data on oral absorption in humans.2

What about heart and kidney?

In a mouse model of pressure-overload heart failure SLU-PP-332 improved pumping function, reduced fibrosis and extended survival, mainly via ERRγ. In 21-month-old mice protein loss in urine and inflammation in the kidney fell after 8 weeks.34

Which side effects are known?

There are no solid data because SLU-PP-332 has never been tested in humans. In mice no obvious toxicity appeared over 10 days. That does not rule out risks in humans.52

Glossary

Terms explained briefly

Dotted words in the text open these explanations directly.

Agonist
A substance that activates a receptor, like a key that fits and turns the lock.
EC50
Concentration at which a substance reaches half of its maximum effect. Lower means stronger.
ERR
Estrogen-related receptors α, β and γ. Nuclear receptors that control genes for mitochondria, fat burning and endurance. They share only their lineage with oestrogen.
Exercise mimetic
A substance that mimics parts of the effects of exercise in the body without training. So far a research term.
Insulin sensitivity
How well cells respond to insulin. The better, the less insulin the body needs for the same blood sugar.
Metabolic syndrome
A combination of belly fat, high blood lipids, high blood sugar and high blood pressure.
Mitochondria
Power plants of the cell. Inside them fat and sugar are turned into energy using oxygen.
Nuclear receptor
A receptor inside the cell that directly switches genes on or off once activated.
Preclinical
Research before first use in humans, in cell cultures and animal models. Results cannot be transferred directly to humans.
Type IIa fibres
Muscle fibres that are fast but still work with endurance because they have many mitochondria.

Evidence

Sources

Show all 7 sourcesHide sources 4 Studies1 Trial registry2 Database checked 26 Oct 2026

Studies

  1. SLU-PP-332 in obesity and metabolic syndrome (mice)

    Billon et al., Journal of Pharmacology and Experimental Therapeutics, 2024

    DOI 10.1124/jpet.123.001733 PMID 37739806
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  2. SLU-PP-332 as an ERR agonist and endurance in mice

    Billon et al., ACS Chemical Biology, 2023

    DOI 10.1021/acschembio.2c00720 PMID 36988910
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed, PMC (Volltext)
  3. ERR agonists in heart failure (mice)

    Xu et al., Circulation, 2024

    DOI 10.1161/CIRCULATIONAHA.123.066542 PMID 37961903
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed
  4. SLU-PP-332 and the ageing kidney (mice)

    Wang et al., American Journal of Pathology, 2023

    DOI 10.1016/j.ajpath.2023.07.008 PMID 37717940
    Checked 26 Oct 2026 via doi.org, Crossref, PubMed

Trial registry

  1. Search on ClinicalTrials.gov (no trial)

    ClinicalTrials.gov, U.S. National Library of Medicine

    Checked 26 Oct 2026 via ClinicalTrials.gov API v2

Database

  1. Structure of SLU-PP-332 in PubChem

    PubChem, U.S. National Library of Medicine (CID 5338394)

    Checked 26 Oct 2026 via PubChem
  2. SLU-PP-332 in ChEMBL (no clinical phase)

    ChEMBL, EMBL-EBI (CHEMBL4208749, über den InChIKey zugeordnet)

    Checked 26 Oct 2026 via ChEMBL

In the shop

SLU-PP-332 in the catalog

Sizes, prices and shipping times are on the product page.

To the product