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Lexicon
Mitochondria

5-Amino-1MQ Oral

The oral tablet form of the NNMT inhibitor 5-Amino-1MQ, the same metabolic principle without an injection.

1 min read 6 sources

To the product To the sources
White tablet bottle with a black TPD label for 5-Amino-1MQ Oral on a white podium, next to it a large double-ring molecule of blue glass spheres in a bright lab
Preclinical · not approvedLab tested in the shop

Summary

At a glance

Sources checked on 25 Oct 2026

Body weight in 11 days
-5.1 %

Obese mice, injected under the skin, control group +1.4%1

Less abdominal fat
~35 %

Mass of epididymal fat tissue, same food intake1

Half-life (mice)
~7 hours

after injection under the skin, no build-up with repeated doses4

Human trials in the registry
0 trials

no trial with 5-Amino-1MQ on ClinicalTrials.gov, as of 25 Oct 20265

  • 5-Amino-1MQ is a small molecule that inhibits the enzyme NNMT. In fat cells this raised NAD+ and the methyl donor SAM while new fat formation fell.16
  • Obese mice lost 5.1 percent of body weight in 11 days and abdominal fat shrank by about 35 percent. Food intake stayed the same.1
  • In old mice NNMT inhibition helped muscle repair and raised grip strength, even more so together with exercise.34
  • In all these animal studies 5-Amino-1MQ was injected under the skin. For the tablet there are only cell models of the gut wall that suggest good absorption.14
  • ClinicalTrials.gov lists no human trial (as of October 2026). Everything here is preclinical research, not a recommendation.5
Profile

Updated May 2026

Class
NNMT inhibitor

oral

Use
Oral

tablet

Half-life
short
Status
Preclinical

no human data

Sizes
50 mg

2 sizes in the shop

Contents 13 sections
  1. At a glance
  2. What is 5-Amino-1MQ Oral?
  3. How it works
  4. How to take it
  5. Dosing
  6. What the research shows
  7. Research status
  8. Side effects
  9. Storage
  10. Related compounds
  11. FAQ
  12. Glossary
  13. Sources

What is 5-Amino-1MQ Oral?

5-Amino-1MQ Oral is the tablet form of the NNMT inhibitor 5-Amino-1MQ, which you also find as an injection in the lexicon. As a small molecule it is in principle suitable for oral uptake. The metabolic principle is the same, just without an injection.

Up front: purely preclinical, no human data.

Comparison

NNMT inhibition and NAD+ in the lexicon

Which entries target NNMT and which supply NAD+ directly, as stated in the TPD lexicon. Tap a card to open its entry.

Tablet 5-Amino-1MQ Oral NNMT NAD+ 1 of 2 targets
Injection 5-Amino-1MQ NNMT NAD+ 1 of 2 targets Tablet with NAD+ building block 5-Amino + NAD+ (Oral) NNMT NAD+ 2 of 2 targets NAD+ as an injection NAD+ NNMT NAD+ 1 of 2 targets

Simplified: NNMT inhibition is meant to leave more NAD+ in the cell, NAD+ products supply it from outside. Neither is studied as a combination in humans. 12

How it works

Like the injectable form, it inhibits the enzyme NNMT in fat tissue, shifts the methyl metabolism and raises the cellular NAD level. In mice this led to less fat mass without changed eating behavior.

Details on the mechanism are in the 5-Amino-1MQ entry.

Where it acts

Where 5-Amino-1MQ acted in experiments

Tap a point or a card. Colour = NNMT, grey = observed. All from cell and animal studies.

  1. Fat tissue

    NNMT inhibited, more NAD+ and SAM, less new fat formation1

    NNMT
  2. Blood lipids

    Total cholesterol about 30% lower in mice1

    Observed in trials
  3. Skeletal muscle

    Muscle stem cells more active, repair after injury better in old mice3

    NNMT
  4. Liver

    NNMT raised in obese mice, switching it off protected against obesity2

    Observed in trials

Known targets1

Compound PubChem CID 950107: one described target, Inhibitor, in cell assays.

Nicotinamide N-methyltransferase
Gene
NNMT
UniProt
P40261
ChEMBL
CHEMBL2346486
Action
Inhibitor, in cell assays
Translucent fat cells as glass spheres, in the centre a glass enzyme shape holding a small blue molecule, blue ring molecules next to it
5-Amino-1MQ inhibits the enzyme NNMT in fat cells. Symbolic image.

How to take it

Oral, usually one tablet per day with some water, with or without food.

White bottle with a black TPD label for 5-Amino-1MQ Oral on a white tray, next to it a few white tablets and a glass of water
Taken orally with some water, with or without food. Symbolic image.

Dosing

Dosing

Dosing, titration and syringe

Loading the dosing information …

  • Getting started and stepping up, drawn as a staircase
  • Units on the U-100 syringe for every step
  • How long one vial lasts

What the research shows

The basis is the same as the injectable form (Neelakantan, 2018): NNMT inhibition lowered fat mass in obese mice. That is preclinical, human studies are missing. Stay realistic, it does not replace a calorie deficit.

Study results

What the trials measured

Interactive: switch tabs, tap points, show or hide arms. Arms are named relative to each other, no dosing advice.

Fat and weight after 11 days1

Obese mice on a high-fat diet, 9 animals each, injected under the skin

Body weight1 Change from start
Without 5-Amino-1MQ (control) +1.4%
With 5-Amino-1MQ -5.1%
Abdominal fat (mass)1 compared with the control group
With 5-Amino-1MQ -35.0%
Total cholesterol1 compared with the control group
With 5-Amino-1MQ -30.0%

Values from the full text, fat and cholesterol as approximate figures (about 35 and 30 percent). Fat cells were more than 30 percent smaller and food intake did not differ. Given three times a day under the skin, not as a tablet.

Less new fat formation in fat cells1

Fat storage in maturing fat cells (3T3-L1) compared with untreated cells

New fat formation1
Lower concentration -50%
Higher concentration -70%

Cell experiment, two concentrations. At the highest tested concentration cell viability fell slightly.

Grip strength of old mice43

Compared with old mice without exercise and without 5-Amino-1MQ, 8 weeks

Grip strength4
Exercise without 5-Amino-1MQ +20%
With 5-Amino-1MQ +40%
Exercise with 5-Amino-1MQ +60%
Muscle force after injury3 Peak torque, separate study
With 5-Amino-1MQ +70%

Approximate values from the abstracts. Given under the skin in both studies. The effects of 5-Amino-1MQ and exercise added up.

Glass running shoe next to a cluster of white spheres as fat tissue on a bright desk, a green plant beside it
The data come from experiments in mice, human studies are missing. Symbolic image.

Research status

Where the research stands

Where the compound stands on the way from lab research to approval. As of 25 Oct 2026. 5

  1. Preclinical Cell assays and mice, injected under the skin
  2. Phase 1 no registered trial
  3. Phase 2 no registered trial
  4. Phase 3 no registered trial
  5. Approval not yet
Not approved and no registered human trial. 5-Amino-1MQ has only been studied preclinically so far.5

So far there is no registered trial in humans. 5

Side effects

  • Solid human data are missing.
  • Generally reported as well tolerated, but without controlled data.

Storage

Store dry, cool and protected from light, out of reach of children. Keep the original container closed and mind the expiry date.

Three white tablet bottles and a folded light blue towel on a white shelf
Dry, cool and dark in the closed original container. Symbolic image.

Related

Related compounds

Blends with 5-Amino-1MQ Oral or a different path: all in the TPD lexicon.

5-Amino-1MQ Oral
5-Amino-1MQ The same compound as an injection 5-Amino + NAD+ (Oral) Contains 5-Amino-1MQ plus NAD+ building block NAD+ + MOTS-C + 5-Amino-1MQ Blend Contains 5-Amino-1MQ plus NAD+ and MOTS-c NAD+ NAD+ directly MOTS-c Different path: peptide from the mitochondria SLU-PP-332 Different path, also a tablet and purely preclinical

FAQ

Common questions about 5-Amino-1MQ Oral

Short answers, each backed by the sources below.

Are there studies on 5-Amino-1MQ as a tablet?

No. In the published animal studies 5-Amino-1MQ was injected under the skin. For the tablet there are only cell models of the gut wall: there the compound passed membranes well, so the authors expect good absorption. This has not been tested in animals or humans.14

Is 5-Amino-1MQ approved?

No. ClinicalTrials.gov lists no trial with 5-Amino-1MQ (as of 25 October 2026). All data come from cell experiments and mice.5

How does 5-Amino-1MQ work?

It inhibits the enzyme NNMT, which uses up nicotinamide (a precursor of NAD+) with a methyl group from SAM. In fat cells NAD+ and SAM rose and new fat formation fell. When NNMT was switched off in fat tissue and liver of mice, energy expenditure rose and the animals stayed leaner on a high-fat diet.12

What did the study in obese mice show?

After 11 days the treated mice had lost 5.1 percent of their weight while the control group had gained 1.4 percent. Abdominal fat was about 35 percent lighter, fat cells more than 30 percent smaller and cholesterol about 30 percent lower. Both groups ate the same amount.1

What about muscle?

In old mice muscle stem cells became more active after an injury, the cross-section of new fibres nearly twice as large and force about 70 percent higher. In a second study grip strength of old mice rose by about 40 percent, with exercise by about 60 percent. This has not been studied in humans.34

Which side effects are known?

There are no solid human data. In the mouse study the authors saw no observable side effects and no change in food intake. NNMT also occurs in the liver and other tissues, the consequences of long-term inhibition in humans are unknown.12

Glossary

Terms explained briefly

Dotted words in the text open these explanations directly.

Caco-2 cells
Cell model of the gut wall. It estimates how well a substance could pass from the gut into the blood.
Calorie deficit
Taking in less energy than you use. The basis of any weight loss.
Fat mass
Weight of fat tissue, measured separately from the rest of body weight.
Methyl metabolism
Transfer of small methyl groups, mainly from SAM. Among other things it controls which genes are active.
NAD+
Coenzyme for the cell's energy metabolism. It is built from precursors such as nicotinamide.
NNMT
Nicotinamide N-methyltransferase: enzyme that adds a methyl group to nicotinamide. In obesity it is raised in fat tissue.
Preclinical
Only studied in cells and animals, not yet in humans.
SAM
S-adenosylmethionine, the cell's main methyl group donor.
Small molecule
Compound of small size, not a peptide. Such substances can often be absorbed as a tablet.

Evidence

Sources

Show all 6 sourcesHide sources 4 Studies1 Trial registry1 Database checked 25 Oct 2026

Studies

  1. NNMT inhibitors reverse obesity in mice

    Neelakantan et al., Biochemical Pharmacology, 2018

    DOI 10.1016/j.bcp.2017.11.007 PMID 29155147
    Checked 25 Oct 2026 via doi.org, Crossref, PubMed, PubMed Central
  2. Switching off NNMT protects mice from obesity

    Kraus et al., Nature, 2014

    DOI 10.1038/nature13198 PMID 24717514
    Checked 25 Oct 2026 via doi.org, Crossref, PubMed
  3. NNMT inhibitor and muscle repair in old mice

    Neelakantan et al., Biochemical Pharmacology, 2019

    DOI 10.1016/j.bcp.2019.02.008 PMID 30753815
    Checked 25 Oct 2026 via doi.org, Crossref, PubMed, PubMed Central
  4. NNMT inhibition and exercise in old mice

    Dimet-Wiley et al., Scientific Reports, 2024

    DOI 10.1038/s41598-024-66034-9 PMID 38969654
    Checked 25 Oct 2026 via doi.org, Crossref, PubMed, PubMed Central

Trial registry

  1. Search on ClinicalTrials.gov

    ClinicalTrials.gov, U.S. National Library of Medicine

    Checked 25 Oct 2026 via ClinicalTrials.gov API v2

Database

  1. Structure of 5-amino-1-methylquinolinium in PubChem

    PubChem, U.S. National Library of Medicine (CID 950107)

    Checked 25 Oct 2026 via PubChem

In the shop

5-Amino-1MQ Oral in the catalog

Sizes, prices and shipping times are on the product page.

To the product