Superdrol Oil - Research Substance

No. ClinicalTrials.gov lists not a single trial with methasterone, neither as a tablet nor as an oil. In humans there are only case reports from people who had swallowed dietary supplements containing methasterone. Everything here is the state of research, not a recommendation.⁹¹

The compound is the same. There are no data on the oil form, including no measured half-life. In the animal tests for the DEA methasterone acted similarly to testosterone whether injected under the skin or swallowed. The 17-methyl group stays on the molecule in the oil form too.⁸¹⁰

In a series of 5 previously healthy people jaundice appeared 2 weeks after stopping, bilirubin peaked another 2 to 3 weeks after presentation and everything had healed after about 12 weeks. In a review of 52 cases people saw a doctor at a median of 56 days after starting and bilirubin peaked 28 days after stopping. Nobody died or needed a new liver.¹²⁵

In the review of 52 liver injuries from steroids 43 percent also had kidney injury. Single case reports on methasterone describe severe bile congestion with kidney failure and IgA nephropathy.²⁴³

It binds the androgen receptor about as strongly as testosterone and strongly activates it in cell assays, with the effect lasting several days after exposure. It barely bound oestrogen, progesterone or cortisol receptors. In castrated rats it preserved muscle and sex organs like testosterone.⁸⁶

Since 2002 new designer steroids such as methasterone have been sold as dietary supplements. In New York a lab later even found it in vitamin and mineral capsules whose buyers complained of hair loss, fatigue and muscle aches. The US drug agency sent a warning letter about the product over health damage as early as 2006.⁷⁶⁸